Table 1.

Gene ontology enrichment analysis of genes closing or opening in mature neutrophils of MM patients vs HAs

IDDescriptionPAdjusted P
GO:0042119 Neutrophil activation 1.72e−11 3.56e−8 
GO:0043312 Neutrophil degranulation 2.27e−11 3.56e−8 
GO:0002283 Neutrophil activation involved in immune response 2.82e−11 3.56e−8 
GO:0036230 Granulocyte activation 2.83e−11 3.56e−8 
GO:0002446 Neutrophil-mediated immunity 6.15e−11 6.18e−8 
GO:0031325 Positive regulation of cellular metabolic process 1.08e−10 8.60e−8 
GO:0051173 Positive regulation of nitrogen compound metabolic process 1.20e−10 8.60e−8 
GO:0009893 Positive regulation of metabolic process 3.33e−10 2.09e−7 
GO:0043299 Leukocyte degranulation 5.13e−10 2.87e−7 
GO:0002275 Myeloid cell activation involved in immune response 9.00e−10 4.29e−7 
IDDescriptionPAdjusted P
GO:0042119 Neutrophil activation 1.72e−11 3.56e−8 
GO:0043312 Neutrophil degranulation 2.27e−11 3.56e−8 
GO:0002283 Neutrophil activation involved in immune response 2.82e−11 3.56e−8 
GO:0036230 Granulocyte activation 2.83e−11 3.56e−8 
GO:0002446 Neutrophil-mediated immunity 6.15e−11 6.18e−8 
GO:0031325 Positive regulation of cellular metabolic process 1.08e−10 8.60e−8 
GO:0051173 Positive regulation of nitrogen compound metabolic process 1.20e−10 8.60e−8 
GO:0009893 Positive regulation of metabolic process 3.33e−10 2.09e−7 
GO:0043299 Leukocyte degranulation 5.13e−10 2.87e−7 
GO:0002275 Myeloid cell activation involved in immune response 9.00e−10 4.29e−7 

Several functions associated with closed regions predicted for altered neutrophil immunity in MM, while no functions were significantly associated with open regions.

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