Table 1.

ISGs induced by ICA

Gene nameDescriptionFold changeP
Arntl Aryl hydrocarbon receptor nuclear translocator-like 1.64 .00011 
Bst2 Bone marrow stromal cell antigen 2 1.87 .00537 
Cpa3 Carboxypeptidase A3 mast cell 1.83 .00564 
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.06 .03479 
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.13 .00408 
Herc6 Hect domain and RLD 6 1.87 .00195 
Hsh2d Hematopoietic SH2 domain containing 1.66 .01769 
Ifi27l2a Interferon α-inducible protein 27 like 2A 1.89 .01071 
Ifi44 Interferon-induced protein 44 3.05 .00181 
Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 2.10 .01085 
Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 2.07 .00796 
Igkv6-23 Immunoglobulin κ variable 6-23 4.20 .02328 
Irf7 Interferon regulatory factor 7 1.55 .02016 
Isg15 ISG15 ubiquitin-like modifier 2.08 .00542 
Mx1 Myxovirus (influenza virus) resistance 1 2.08 .00989 
Mx2 Myxovirus (influenza virus) resistance 2 2.55 .00052 
Lpl Lipoprotein lipase 1.92 .03890 
Oas1a 2'-5′ Oligoadenylate synthetase 1A 1.64 .00308 
Oas1b 2'-5′ Oligoadenylate synthetase 1B 2.19 .00462 
Oas1g 2'-5′ Oligoadenylate synthetase 1G 1.75 .00343 
Oas2 2'-5′ Oligoadenylate synthetase 2 3.29 .00255 
Oas3 2'-5′ Oligoadenylate synthetase 3 1.78 .01963 
Oasl1 2'-5′ Oligoadenylate synthetase-like 1 1.65 .01097 
Oasl2 2'-5′ Oligoadenylate synthetase-like 2 1.68 .01201 
Parp11 Poly (ADP-ribose) polymerase family member 11 1.51 .00655 
Rnf213 Ring finger protein 213 1.83 .00128 
Rsad2 Radical S-adenosyl methionine domain containing 2 2.27 .01089 
Rtp4 Receptor transporter protein 4 1.62 .02657 
Sass6 Spindle assembly 6 homolog (Caenorhabditis elegans1.55 .00132 
Slfn2 Schlafen 2 1.57 .01767 
Slfn4 Schlafen 4 3.46 .00182 
Slfn5 Schlafen 5 2.00 .00092 
Trim30a Tripartite motif-containing 30A 2.10 .00866 
Trim34a Tripartite motif-containing 34A 1.74 .02671 
Usp18 Ubiquitin specific peptidase 18 2.71 .00332 
Xaf1 XIAP associated factor 1 1.71 .00268 
Gene nameDescriptionFold changeP
Arntl Aryl hydrocarbon receptor nuclear translocator-like 1.64 .00011 
Bst2 Bone marrow stromal cell antigen 2 1.87 .00537 
Cpa3 Carboxypeptidase A3 mast cell 1.83 .00564 
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.06 .03479 
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.13 .00408 
Herc6 Hect domain and RLD 6 1.87 .00195 
Hsh2d Hematopoietic SH2 domain containing 1.66 .01769 
Ifi27l2a Interferon α-inducible protein 27 like 2A 1.89 .01071 
Ifi44 Interferon-induced protein 44 3.05 .00181 
Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 2.10 .01085 
Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 2.07 .00796 
Igkv6-23 Immunoglobulin κ variable 6-23 4.20 .02328 
Irf7 Interferon regulatory factor 7 1.55 .02016 
Isg15 ISG15 ubiquitin-like modifier 2.08 .00542 
Mx1 Myxovirus (influenza virus) resistance 1 2.08 .00989 
Mx2 Myxovirus (influenza virus) resistance 2 2.55 .00052 
Lpl Lipoprotein lipase 1.92 .03890 
Oas1a 2'-5′ Oligoadenylate synthetase 1A 1.64 .00308 
Oas1b 2'-5′ Oligoadenylate synthetase 1B 2.19 .00462 
Oas1g 2'-5′ Oligoadenylate synthetase 1G 1.75 .00343 
Oas2 2'-5′ Oligoadenylate synthetase 2 3.29 .00255 
Oas3 2'-5′ Oligoadenylate synthetase 3 1.78 .01963 
Oasl1 2'-5′ Oligoadenylate synthetase-like 1 1.65 .01097 
Oasl2 2'-5′ Oligoadenylate synthetase-like 2 1.68 .01201 
Parp11 Poly (ADP-ribose) polymerase family member 11 1.51 .00655 
Rnf213 Ring finger protein 213 1.83 .00128 
Rsad2 Radical S-adenosyl methionine domain containing 2 2.27 .01089 
Rtp4 Receptor transporter protein 4 1.62 .02657 
Sass6 Spindle assembly 6 homolog (Caenorhabditis elegans1.55 .00132 
Slfn2 Schlafen 2 1.57 .01767 
Slfn4 Schlafen 4 3.46 .00182 
Slfn5 Schlafen 5 2.00 .00092 
Trim30a Tripartite motif-containing 30A 2.10 .00866 
Trim34a Tripartite motif-containing 34A 1.74 .02671 
Usp18 Ubiquitin specific peptidase 18 2.71 .00332 
Xaf1 XIAP associated factor 1 1.71 .00268 

Table lists the group B genes (group B genes are those upregulated by ICA in TCD-BM + T transplanted animals; see Figure 6) that were identified as ISGs by Interferome database analysis.

or Create an Account

Close Modal
Close Modal