Mouse and orthologous human genes with consistent contribution to arterial thrombosis with(out) altered bleeding
| Altered phenotype . | Mouse deficiency . | Human ortholog . |
|---|---|---|
| Antithrombotic, no prolonged bleeding | ||
| Plasma coagulation | F11, F12 | F11*, F12* |
| Plasma fibrinolysis | Serpine1 | SERPINE1 |
| Platelet membrane | Dusp3, Gp6, Itga6, P2rx1, Selp | DUSP3, GP6*, ITGA6, P2RX1, SELP |
| Platelet signaling | Csnk2b,Pik3c3, Pik3cg, Pld1, Ppia, Prkca, Rhog, S100a9, Sgk1 | CSNK2B, PIK3C3, PIK3CG, PLD1, PPIA, PRKCA, RHOG, S100A9, SGK1 |
| Antithrombotic, prolonged bleeding | ||
| Coagulation | F2, F8, F9, Klkb1, Vwf | F2*, F8, F9, KLKB1, VWF* |
| Platelets | ||
| Membrane proteins | Ano6, Clec1b, F2rl3, Fcer1g, Fermt3, Gna13, Gnaq, Gp1ba, GP1bb, Itga2, Itgb3, Mertk, Orai1, P2ry1, P2ry12, Pdia3, Pdia4, Ptprj, Stim1, Trpm7, Tspan32 | ANO6, CLEC1B, F2RL3*, FCER1G, FERMT3, GNA13, GNAQ, GPIBA*, GPIBB, ITGA2, ITGB3*, MERTK, ORAI1, P2RY1, P2RY12*, PDIA3, PDIA4, PTPRJ, STIM1, TRPM7, TSPAN32 |
| Signaling | Csk, Map3k5, Mapk8, Mapk14, Pdpk1, Pik3cb, Plcg2, Rac1, Rasgrp2, Tln1 | CSK, MAP3K5, MAPK8, MAPK14, PDPK1, PIK3CB*, PLCG2, RAC1, RASGRP2, TLN1 |
| Secretion/activation | Nbeal2, Kcnip3, Mmp2 | NBEAL2, KCNIP3, MMP2 |
| Vessel wall | Bambi, Bdkrb2,Mfap2 | BAMBI, BDKRB2, MFAP2 |
| Not antithrombotic, prolonged bleeding | ||
| Vessel wall | Ceacam1/2 | CEACAM1 |
| Altered phenotype . | Mouse deficiency . | Human ortholog . |
|---|---|---|
| Antithrombotic, no prolonged bleeding | ||
| Plasma coagulation | F11, F12 | F11*, F12* |
| Plasma fibrinolysis | Serpine1 | SERPINE1 |
| Platelet membrane | Dusp3, Gp6, Itga6, P2rx1, Selp | DUSP3, GP6*, ITGA6, P2RX1, SELP |
| Platelet signaling | Csnk2b,Pik3c3, Pik3cg, Pld1, Ppia, Prkca, Rhog, S100a9, Sgk1 | CSNK2B, PIK3C3, PIK3CG, PLD1, PPIA, PRKCA, RHOG, S100A9, SGK1 |
| Antithrombotic, prolonged bleeding | ||
| Coagulation | F2, F8, F9, Klkb1, Vwf | F2*, F8, F9, KLKB1, VWF* |
| Platelets | ||
| Membrane proteins | Ano6, Clec1b, F2rl3, Fcer1g, Fermt3, Gna13, Gnaq, Gp1ba, GP1bb, Itga2, Itgb3, Mertk, Orai1, P2ry1, P2ry12, Pdia3, Pdia4, Ptprj, Stim1, Trpm7, Tspan32 | ANO6, CLEC1B, F2RL3*, FCER1G, FERMT3, GNA13, GNAQ, GPIBA*, GPIBB, ITGA2, ITGB3*, MERTK, ORAI1, P2RY1, P2RY12*, PDIA3, PDIA4, PTPRJ, STIM1, TRPM7, TSPAN32 |
| Signaling | Csk, Map3k5, Mapk8, Mapk14, Pdpk1, Pik3cb, Plcg2, Rac1, Rasgrp2, Tln1 | CSK, MAP3K5, MAPK8, MAPK14, PDPK1, PIK3CB*, PLCG2, RAC1, RASGRP2, TLN1 |
| Secretion/activation | Nbeal2, Kcnip3, Mmp2 | NBEAL2, KCNIP3, MMP2 |
| Vessel wall | Bambi, Bdkrb2,Mfap2 | BAMBI, BDKRB2, MFAP2 |
| Not antithrombotic, prolonged bleeding | ||
| Vessel wall | Ceacam1/2 | CEACAM1 |
Mouse genes are listed with n ≥ 3 scaled studies (5-point) and CP values of >2.30 (P < .05). Phenotype classification was according to reported changes regarding plasma, platelet, or vascular phenotypes. Bold indicates mouse deficiency resulting in a highly prolonged bleeding (class IV, score −2).
Human orthologs targeted in current clinical practice or trials.