Biological pathways associated with differentially expressed genes between each sample group
| . | Upregulated . | Downregulated . |
|---|---|---|
| Healthy R848 vs healthy CD40L | No significant pathways | Ribosome |
| Cytokine-cytokine receptor interaction | ||
| Metabolism/gluconeogenesis | ||
| Amino acid synthesis | ||
| All WM vs all healthy | MAPK signaling pathway | No significant pathways |
| NF-κB pathway | ||
| Cytokine-cytokine receptor interaction | ||
| WM CD40L vs healthy CD40L | Cytokine-cytokine receptor interaction | JAK-STAT signaling pathway |
| TNF signaling pathway | Endocytosis | |
| TLR signaling pathway | NK cell–mediated cytotoxicity | |
| NF-κB pathway | FOXO signaling pathway | |
| Apoptosis | Glycosaminoglycan biosynthesis | |
| Chemokine signaling pathway | ||
| WM R848 vs healthy R848 | Cell adhesion molecules/focal adhesion | Protein processing in ER |
| TNF signaling pathway | ||
| TLR signaling pathway | ||
| NF-κB pathway | ||
| Cytokine-cytokine receptor interaction | ||
| PI3K-AKT signaling | ||
| WM R848 vs WM CD40L | Antigen processing and presentation | Ribosome/ribosome biogenesis |
| NK cell–mediated cytotoxicity | Spliceosome | |
| ECM-receptor interaction | Cell cycle/DNA replication | |
| PI3K-AKT signaling pathway | Glycolysis | |
| Endocytosis | RNA transport/RNA degradation | |
| Choline metabolism in cancer | Purine/pyrimidine metabolism | |
| Leukocyte transendothelial migration | ||
| Regulation of actin cytoskeleton |
| . | Upregulated . | Downregulated . |
|---|---|---|
| Healthy R848 vs healthy CD40L | No significant pathways | Ribosome |
| Cytokine-cytokine receptor interaction | ||
| Metabolism/gluconeogenesis | ||
| Amino acid synthesis | ||
| All WM vs all healthy | MAPK signaling pathway | No significant pathways |
| NF-κB pathway | ||
| Cytokine-cytokine receptor interaction | ||
| WM CD40L vs healthy CD40L | Cytokine-cytokine receptor interaction | JAK-STAT signaling pathway |
| TNF signaling pathway | Endocytosis | |
| TLR signaling pathway | NK cell–mediated cytotoxicity | |
| NF-κB pathway | FOXO signaling pathway | |
| Apoptosis | Glycosaminoglycan biosynthesis | |
| Chemokine signaling pathway | ||
| WM R848 vs healthy R848 | Cell adhesion molecules/focal adhesion | Protein processing in ER |
| TNF signaling pathway | ||
| TLR signaling pathway | ||
| NF-κB pathway | ||
| Cytokine-cytokine receptor interaction | ||
| PI3K-AKT signaling | ||
| WM R848 vs WM CD40L | Antigen processing and presentation | Ribosome/ribosome biogenesis |
| NK cell–mediated cytotoxicity | Spliceosome | |
| ECM-receptor interaction | Cell cycle/DNA replication | |
| PI3K-AKT signaling pathway | Glycolysis | |
| Endocytosis | RNA transport/RNA degradation | |
| Choline metabolism in cancer | Purine/pyrimidine metabolism | |
| Leukocyte transendothelial migration | ||
| Regulation of actin cytoskeleton |
Comparisons of cell source and stimulation conditions are shown in the first column. Terms associated with genes that were upregulated or downregulated in the comparators indicated in bold are listed.
ECM, extracellular matrix; ER, endoplasmic reticulum; NK, natural killer; PI3K, phosphatidylinositol 3-kinase.