Dysregulated genes in dysbiotic mice, common to both spleen and MLNs
| Gene name . | Protein role . | Fold change . | P . |
|---|---|---|---|
| Cd22 | Localization of B cells; regulates B-cell antigen receptor signaling | Spleen: −1.418 | Spleen: .024 |
| MLN: −1.264 | MLN: .048 | ||
| Cd5 | Scavenger receptor found mainly on T lymphocytes. May regulate T-cell proliferation. | Spleen: −1.533 | Spleen: .050 |
| MLN: −1.337 | MLN: .008 | ||
| Cd6 | Signaling cascade triggered by activation of TCR/CD3 complex, Cell adhesion and costimulatory molecule, PRR that bind LPS and lipoteichoic acid of Gram negative and positive bacteria, respectively. | Spleen: −1.615 | Spleen: .047 |
| MLN: −1.316 | MLN: .006 | ||
| Cd79a | Initiation of signal transduction after antigen binding B-cell antigen receptor | Spleen: −1.448 | Spleen: .008 |
| MLN: −1.394 | MLN: .015 | ||
| Map4k2 | B-cell differentiation in germinal centers | Spleen: −1.321 | Spleen: .002 |
| MLN: −1.384 | MLN: .001 | ||
| Nfatc2 | Induces T-cell cytokines IL-2, -3, and -4; TNF-α; and GM-CSF | Spleen: −1.351 | Spleen: .028 |
| MLN: −1.274 | MLN: .026 | ||
| Tap1 | Transport antigens to the endoplasmic reticulum for association with major histocompatibility complex-1 | Spleen: −1.477 | Spleen: .004 |
| MLN: −1.356 | MLN: .034 | ||
| Tlr1 | Innate immune response to microbial lipopeptides | Spleen: −1.291 | Spleen: .036 |
| MLN: −1.291 | MLN: .025 |
| Gene name . | Protein role . | Fold change . | P . |
|---|---|---|---|
| Cd22 | Localization of B cells; regulates B-cell antigen receptor signaling | Spleen: −1.418 | Spleen: .024 |
| MLN: −1.264 | MLN: .048 | ||
| Cd5 | Scavenger receptor found mainly on T lymphocytes. May regulate T-cell proliferation. | Spleen: −1.533 | Spleen: .050 |
| MLN: −1.337 | MLN: .008 | ||
| Cd6 | Signaling cascade triggered by activation of TCR/CD3 complex, Cell adhesion and costimulatory molecule, PRR that bind LPS and lipoteichoic acid of Gram negative and positive bacteria, respectively. | Spleen: −1.615 | Spleen: .047 |
| MLN: −1.316 | MLN: .006 | ||
| Cd79a | Initiation of signal transduction after antigen binding B-cell antigen receptor | Spleen: −1.448 | Spleen: .008 |
| MLN: −1.394 | MLN: .015 | ||
| Map4k2 | B-cell differentiation in germinal centers | Spleen: −1.321 | Spleen: .002 |
| MLN: −1.384 | MLN: .001 | ||
| Nfatc2 | Induces T-cell cytokines IL-2, -3, and -4; TNF-α; and GM-CSF | Spleen: −1.351 | Spleen: .028 |
| MLN: −1.274 | MLN: .026 | ||
| Tap1 | Transport antigens to the endoplasmic reticulum for association with major histocompatibility complex-1 | Spleen: −1.477 | Spleen: .004 |
| MLN: −1.356 | MLN: .034 | ||
| Tlr1 | Innate immune response to microbial lipopeptides | Spleen: −1.291 | Spleen: .036 |
| MLN: −1.291 | MLN: .025 |