Factors associated with late clinical complications (whatever their type)
| Variable . | IRR (95% CI) . | P* . | aIRR (95% CI) . | P* . |
|---|---|---|---|---|
| Molecular diagnosis (ARTEMIS) | 4.4 (2.5-7.7) | <.0001 | 3.2 (2.1-4.9) | <.0001 |
| Viral infection prior to HCT | 2.2 (1.1-4.3) | .02 | 1.7 (1.2-2.6) | .008 |
| Myeloablative conditioning | 2.0 (1.0-3.8) | .05 | ||
| Any alkylator therapy | 3.0 (1.6-5.6) | .001 | 3.1 (2.0-4.9) | <.0001 |
| Donor identity | .007 | |||
| MSD | 1 | |||
| MFD | 1.0 (0.3-3.) | 1.0 | ||
| MMFD | 1.8 (0.5-6.2) | .4 | ||
| Haploidentical | 3.5 (1.5-9.8) | .001 | ||
| MUD | 1.2 (0.3-4.6) | .8 | ||
| Retransplantation | 2.3 (1.1-4.8) | .03 | ||
| Boost | 2.6 (1.3-5.3) | .009 | ||
| Additional procedure (re-HCT, boost) | 3.2 (1.7-5.9) | <.0001 | 2.0 (1.3-3.0) | .001 |
| IVIG requirement | 3.0 (1.7-5.5) | <.0001 | 1.9 (1.2-3.0) | <.0001 |
| Variable . | IRR (95% CI) . | P* . | aIRR (95% CI) . | P* . |
|---|---|---|---|---|
| Molecular diagnosis (ARTEMIS) | 4.4 (2.5-7.7) | <.0001 | 3.2 (2.1-4.9) | <.0001 |
| Viral infection prior to HCT | 2.2 (1.1-4.3) | .02 | 1.7 (1.2-2.6) | .008 |
| Myeloablative conditioning | 2.0 (1.0-3.8) | .05 | ||
| Any alkylator therapy | 3.0 (1.6-5.6) | .001 | 3.1 (2.0-4.9) | <.0001 |
| Donor identity | .007 | |||
| MSD | 1 | |||
| MFD | 1.0 (0.3-3.) | 1.0 | ||
| MMFD | 1.8 (0.5-6.2) | .4 | ||
| Haploidentical | 3.5 (1.5-9.8) | .001 | ||
| MUD | 1.2 (0.3-4.6) | .8 | ||
| Retransplantation | 2.3 (1.1-4.8) | .03 | ||
| Boost | 2.6 (1.3-5.3) | .009 | ||
| Additional procedure (re-HCT, boost) | 3.2 (1.7-5.9) | <.0001 | 2.0 (1.3-3.0) | .001 |
| IVIG requirement | 3.0 (1.7-5.5) | <.0001 | 1.9 (1.2-3.0) | <.0001 |
n = 92 patients (still alive >2 y post-HCT). The procedure xtmepoisson Stata was used to model data to count the number of events over time. Patients were clustered using a group variable to take into account the practice variations between centers. Because of colinearity with donor identity, conditioning regimen was deleted from the multivariate modeling.
aIRR, adjusted incidence rate of ratio; MFD, matched family donor; MMFD, mismatched family donor; MSD, matched sibling donor; MUD, matched unrelated donor.
P values are referring to univariate analysis (left column) and multivariate analysis (right column), respectively. Only significant results in univariate analysis are shown.