Factors associated with death in survival analysis
| Variable . | HR (95% CI) . | P* . | aHR (95% CI) . | P* . |
|---|---|---|---|---|
| Molecular diagnosis (ARTEMIS) | 0.9 (0.7-1.0) | .07 | ||
| Viral infection prior to transplantation | 2.9 (2.1-4.0) | <.0001 | 3.1 (2.2-4.3) | <.0001 |
| Age in mo at diagnosis (≥3 mo) | 1.8 (1.4-2.4) | <.0001 | 1.5 (1.1-1.9) | .003 |
| Myeloablative conditioning | 1.5 (1.0-2.3) | .05 | ||
| Donor identity | .003 | |||
| MSD | 1 | |||
| MFD | 0.9 (0.3-2.6) | .8 | ||
| MMFD | 5.4 (1.9-15.4) | .001 | ||
| Haploidentical | 4.5 (1.0-20.9) | .06 | ||
| MUD | 3.6 (2.4-5.3) | <.0001 | ||
| Retransplantation | 2.5 (1.5-4.1) | .001 | 2.2 (1.4-3.4) | .001 |
| Additional procedure (re-HCT, boost) | 1.6 (1.2-2.2) | .003 | ||
| Early infection (≤2 y post-HCT) | 1.9 (1.0-3.7) | .04 | ||
| Chronic GVHD (≤2 y post-HCT) | 1.5 (1.2-1.7) | <.0001 | 1.3 (1.2-1.5) | <.0001 |
| Variable . | HR (95% CI) . | P* . | aHR (95% CI) . | P* . |
|---|---|---|---|---|
| Molecular diagnosis (ARTEMIS) | 0.9 (0.7-1.0) | .07 | ||
| Viral infection prior to transplantation | 2.9 (2.1-4.0) | <.0001 | 3.1 (2.2-4.3) | <.0001 |
| Age in mo at diagnosis (≥3 mo) | 1.8 (1.4-2.4) | <.0001 | 1.5 (1.1-1.9) | .003 |
| Myeloablative conditioning | 1.5 (1.0-2.3) | .05 | ||
| Donor identity | .003 | |||
| MSD | 1 | |||
| MFD | 0.9 (0.3-2.6) | .8 | ||
| MMFD | 5.4 (1.9-15.4) | .001 | ||
| Haploidentical | 4.5 (1.0-20.9) | .06 | ||
| MUD | 3.6 (2.4-5.3) | <.0001 | ||
| Retransplantation | 2.5 (1.5-4.1) | .001 | 2.2 (1.4-3.4) | .001 |
| Additional procedure (re-HCT, boost) | 1.6 (1.2-2.2) | .003 | ||
| Early infection (≤2 y post-HCT) | 1.9 (1.0-3.7) | .04 | ||
| Chronic GVHD (≤2 y post-HCT) | 1.5 (1.2-1.7) | <.0001 | 1.3 (1.2-1.5) | <.0001 |
Only significant results in univariate analysis are shown. The hazard proportionality assumption was verified for all variables. Patients were clustered using a group variable to take into account the practice variations between centers.
aHR, adjusted hazard ratio; HR, hazard ratio; MFD, matched family donor; MMFD, mismatched family donor; MSD, matched sibling donor; MUD, matched unrelated donor.
P values are referring to univariate analysis (left column) and multivariate analysis (right column), respectively.