IPA analysis of 561 genes with concordant expression in in Gr1CD11bPOS cells isolated from mice with TF, EPCR, and PAR2 deficiency
| Upstream regulator . | Activation Z-score . | Activation state . | P value of overlap . | Target molecule ratio . |
|---|---|---|---|---|
| TICAM1 | −3.36 | Inhibited | 4.97 × 10−9 | 14/15 |
| LPS | −5.28 | Inhibited | 1.60 × 10−8 | 44/57 |
| TLR4 | −2.86 | Inhibited | 3.69 × 10−8 | 12/20 |
| Interferon γ | −3.51 | Inhibited | 3.75 × 10−8 | 32/47 |
| MYD88 | −3.31 | Inhibited | 5.07 × 10−8 | 16/17 |
| TLR3 | −2.51 | Inhibited | 4.26 × 10−7 | 11/16 |
| Poly r(I:C) | −3.36 | Inhibited | 9.33 × 10−6 | 18/20 |
| IRF8 | −1.84 | Bias | 2.13 × 10−6 | — |
| IRF7 | −2.72 | Inhibited | 2.02 × 10−5 | 10 of 11 |
| IRF3 | −1.66 | Bias | 4.89 × 10−4 | — |
| Upstream regulator . | Activation Z-score . | Activation state . | P value of overlap . | Target molecule ratio . |
|---|---|---|---|---|
| TICAM1 | −3.36 | Inhibited | 4.97 × 10−9 | 14/15 |
| LPS | −5.28 | Inhibited | 1.60 × 10−8 | 44/57 |
| TLR4 | −2.86 | Inhibited | 3.69 × 10−8 | 12/20 |
| Interferon γ | −3.51 | Inhibited | 3.75 × 10−8 | 32/47 |
| MYD88 | −3.31 | Inhibited | 5.07 × 10−8 | 16/17 |
| TLR3 | −2.51 | Inhibited | 4.26 × 10−7 | 11/16 |
| Poly r(I:C) | −3.36 | Inhibited | 9.33 × 10−6 | 18/20 |
| IRF8 | −1.84 | Bias | 2.13 × 10−6 | — |
| IRF7 | −2.72 | Inhibited | 2.02 × 10−5 | 10 of 11 |
| IRF3 | −1.66 | Bias | 4.89 × 10−4 | — |
Pathways controlled by the indicated upstream regulators are inhibited in mice with receptor deficiency.