Changes in gene expression in PBMCs that was significantly greater in patients with EM than in those without EM resulting from mogamulizumab treatment
| Gene . | With EM, mean (n = 16) . | Without EM, mean (n = 8) . | All patients, mean (N = 24) . | Fold change* . | P . |
|---|---|---|---|---|---|
| HLA-G | 2.19 | 0.10 | 1.49 | 22.20 | .020 |
| TNFRSF17 | 56.87 | 6.57 | 40.10 | 8.66 | .029 |
| CD8B | 13.90 | 1.62 | 9.81 | 8.60 | .009 |
| GZMK | 10.46 | 1.37 | 7.43 | 7.63 | .037 |
| CD40LG | 5.38 | 0.80 | 3.85 | 6.74 | .018 |
| LRG1 | 8.61 | 1.47 | 6.23 | 5.84 | .045 |
| JCHAIN | 27.59 | 5.07 | 20.08 | 5.44 | .036 |
| CD8A | 9.96 | 2.08 | 7.34 | 4.79 | .027 |
| IDO2 | 3.70 | 0.84 | 2.75 | 4.43 | .021 |
| IL4 | 3.54 | 1.02 | 2.70 | 3.47 | .026 |
| CDKN3 | 3.38 | 1.13 | 2.63 | 2.99 | .035 |
| CCL4 | 3.95 | 1.43 | 3.11 | 2.76 | .039 |
| GZMA | 5.02 | 1.82 | 3.95 | 2.76 | .025 |
| BCL2 | 1.66 | 0.60 | 1.31 | 2.76 | .011 |
| ITGAX | 3.43 | 1.36 | 2.74 | 2.52 | .007 |
| NCF1 | 6.18 | 2.55 | 4.97 | 2.43 | .017 |
| BCL6 | 2.65 | 1.10 | 2.13 | 2.40 | .017 |
| ITGB2 | 2.21 | 0.96 | 1.79 | 2.30 | .007 |
| LILRB2 | 3.97 | 1.78 | 3.24 | 2.23 | .037 |
| STAT4 | 2.59 | 1.29 | 2.15 | 2.01 | .033 |
| NCAM1 | 3.17 | 1.59 | 2.64 | 1.99 | .041 |
| CD83 | 1.25 | 0.63 | 1.05 | 1.98 | .041 |
| HLA-DMA | 2.35 | 1.25 | 1.98 | 1.88 | .015 |
| G6PD | 2.06 | 1.16 | 1.76 | 1.78 | .001 |
| BCL2L11 | 1.79 | 1.02 | 1.53 | 1.75 | .021 |
| CD74 | 1.91 | 1.11 | 1.64 | 1.71 | .050 |
| C10orf54 | 1.38 | 0.88 | 1.21 | 1.57 | .024 |
| STAT5A | 1.27 | 0.83 | 1.12 | 1.53 | .042 |
| Gene . | With EM, mean (n = 16) . | Without EM, mean (n = 8) . | All patients, mean (N = 24) . | Fold change* . | P . |
|---|---|---|---|---|---|
| HLA-G | 2.19 | 0.10 | 1.49 | 22.20 | .020 |
| TNFRSF17 | 56.87 | 6.57 | 40.10 | 8.66 | .029 |
| CD8B | 13.90 | 1.62 | 9.81 | 8.60 | .009 |
| GZMK | 10.46 | 1.37 | 7.43 | 7.63 | .037 |
| CD40LG | 5.38 | 0.80 | 3.85 | 6.74 | .018 |
| LRG1 | 8.61 | 1.47 | 6.23 | 5.84 | .045 |
| JCHAIN | 27.59 | 5.07 | 20.08 | 5.44 | .036 |
| CD8A | 9.96 | 2.08 | 7.34 | 4.79 | .027 |
| IDO2 | 3.70 | 0.84 | 2.75 | 4.43 | .021 |
| IL4 | 3.54 | 1.02 | 2.70 | 3.47 | .026 |
| CDKN3 | 3.38 | 1.13 | 2.63 | 2.99 | .035 |
| CCL4 | 3.95 | 1.43 | 3.11 | 2.76 | .039 |
| GZMA | 5.02 | 1.82 | 3.95 | 2.76 | .025 |
| BCL2 | 1.66 | 0.60 | 1.31 | 2.76 | .011 |
| ITGAX | 3.43 | 1.36 | 2.74 | 2.52 | .007 |
| NCF1 | 6.18 | 2.55 | 4.97 | 2.43 | .017 |
| BCL6 | 2.65 | 1.10 | 2.13 | 2.40 | .017 |
| ITGB2 | 2.21 | 0.96 | 1.79 | 2.30 | .007 |
| LILRB2 | 3.97 | 1.78 | 3.24 | 2.23 | .037 |
| STAT4 | 2.59 | 1.29 | 2.15 | 2.01 | .033 |
| NCAM1 | 3.17 | 1.59 | 2.64 | 1.99 | .041 |
| CD83 | 1.25 | 0.63 | 1.05 | 1.98 | .041 |
| HLA-DMA | 2.35 | 1.25 | 1.98 | 1.88 | .015 |
| G6PD | 2.06 | 1.16 | 1.76 | 1.78 | .001 |
| BCL2L11 | 1.79 | 1.02 | 1.53 | 1.75 | .021 |
| CD74 | 1.91 | 1.11 | 1.64 | 1.71 | .050 |
| C10orf54 | 1.38 | 0.88 | 1.21 | 1.57 | .024 |
| STAT5A | 1.27 | 0.83 | 1.12 | 1.53 | .042 |
Fold change is indicated as “with EM/without EM.”