Characteristics of the NK-cell doses, donor/recipient KIR characteristics, and infusional toxicities
| Patient . | NK cells per dose, /kg . | No. of doses . | Patient KIR ligand . | Donor KIR ligand . | NK alloreactivity . | Donor KIR haplotype . | No. of Cen B/B . | KIR score . | KIR centromeric . | KIR 2DS1 . | Toxicity . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 × 104 | 2 | C2/C2, BW4 | C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 2 | 1 × 105 | 3 | C1/C2, Bw4 | C1, Bw4 | No | A/B | 2 | Better | Cen-A/B | No | None |
| 3 | 1 × 105 | 3 | C1/C2, Bw4 | C1/C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 4 | 1 × 106 | 3 | C1/C1, Bw4 | C1/C2, Bw4 | Yes | A/B | 2 | Better | Cen-A/B | No | None |
| 5 | 1 × 106 | 3 | C1/C1 | C1/C2, Bw4 | Yes | A/A | 0 | Neutral | Cen-A/A | No | None |
| 6 | 1 × 106 | 2 | C1/C2, Bw4 | C1/C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 7 | 1 × 107 | 3 | C1/C2, Bw4 | C1, Bw4 | No | A/B | 2 | Best | Cen-B/B | Yes | None |
| 8 | 1 × 107 | 3 | C1/C1, Bw4 | C1, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 9 | 1 × 107 | 3 | C1/C1, Bw4 | C1/C1, Bw4 | No | A/B | 0 | Neutral | Cen-A/B | Yes | None |
| 10 | 3 × 107 | 3 | C1/C1 | C1/C2 | Yes | A/B | 2 | Better | Cen-A, Cen/Tel-B | No | None |
| 11 | 3 × 107 | 3 | C2/C2, Bw4 | C1/C2, Bw4 | Yes | A/B | 2 | Better | Cen-A/B | Yes | None |
| 12 | 1 × 108 | 3 | C1/C1, Bw4 | C1/C2, Bw4 | Yes | B/B | 0 | Neutral | Cen/Tel-B | Yes | None |
| 13 | 1 × 108 | 3 | C1/C1, Bw6 | C1/C1, Bw6 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| Patient . | NK cells per dose, /kg . | No. of doses . | Patient KIR ligand . | Donor KIR ligand . | NK alloreactivity . | Donor KIR haplotype . | No. of Cen B/B . | KIR score . | KIR centromeric . | KIR 2DS1 . | Toxicity . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 × 104 | 2 | C2/C2, BW4 | C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 2 | 1 × 105 | 3 | C1/C2, Bw4 | C1, Bw4 | No | A/B | 2 | Better | Cen-A/B | No | None |
| 3 | 1 × 105 | 3 | C1/C2, Bw4 | C1/C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 4 | 1 × 106 | 3 | C1/C1, Bw4 | C1/C2, Bw4 | Yes | A/B | 2 | Better | Cen-A/B | No | None |
| 5 | 1 × 106 | 3 | C1/C1 | C1/C2, Bw4 | Yes | A/A | 0 | Neutral | Cen-A/A | No | None |
| 6 | 1 × 106 | 2 | C1/C2, Bw4 | C1/C2, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 7 | 1 × 107 | 3 | C1/C2, Bw4 | C1, Bw4 | No | A/B | 2 | Best | Cen-B/B | Yes | None |
| 8 | 1 × 107 | 3 | C1/C1, Bw4 | C1, Bw4 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
| 9 | 1 × 107 | 3 | C1/C1, Bw4 | C1/C1, Bw4 | No | A/B | 0 | Neutral | Cen-A/B | Yes | None |
| 10 | 3 × 107 | 3 | C1/C1 | C1/C2 | Yes | A/B | 2 | Better | Cen-A, Cen/Tel-B | No | None |
| 11 | 3 × 107 | 3 | C2/C2, Bw4 | C1/C2, Bw4 | Yes | A/B | 2 | Better | Cen-A/B | Yes | None |
| 12 | 1 × 108 | 3 | C1/C1, Bw4 | C1/C2, Bw4 | Yes | B/B | 0 | Neutral | Cen/Tel-B | Yes | None |
| 13 | 1 × 108 | 3 | C1/C1, Bw6 | C1/C1, Bw6 | No | A/A | 0 | Neutral | Cen-A/A | No | None |
Cen, centromere.