Table 1. MK-2048 upregulates the... | American Society of Hematology

Table 1.

MK-2048 upregulates the expression of UPR-related genes

Gene symbol	Gene description	Log2 ratio
Gene symbol	Gene description	KK1	SLB-1	ED	Average
CHAC1	ChaC glutathione-specific γ-glutamylcyclotransferase 1	5.61*	4.48*	4.38*	4.82*
TRIB3	Tribbles pseudokinase 3	3.45*	3.51*	1.25*	2.74*
CHOP/DDIT3	DNA damage-inducible transcript 3	2.36*	2.04*	1.42*	1.94*
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	2.06*	2.28*	1.46*	1.93*
ATF3	Activating transcription factor 3	2.68*	2.08*	0.82*	1.86*
XBP1	X-box binding protein 1	1.21*	2.22*	1.58*	1.67*
IRE1/ERN1	ER to nucleus signaling 1	1.06*	2.41*	‡	1.16*
ATF4	Activating transcription factor 4	1.16*	1.33*	0.84†	1.11*
GADD34/PPP1R15A	Protein phosphatase 1, regulatory subunit 15A	1.47*	1.84*	‡	1.10*
WARS	Tryptophanyl-tRNA synthetase	1.45*	0.98†	0.88†	1.10*
EDEM1	ER degradation enhancer, mannosidase α-like 1	1.23*	0.82†	0.53†	0.86*
ERDJ4/DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	1.23*	1.25*	‡	0.83*

Gene symbol	Gene description	Log2 ratio
Gene symbol	Gene description	KK1	SLB-1	ED	Average
CHAC1	ChaC glutathione-specific γ-glutamylcyclotransferase 1	5.61*	4.48*	4.38*	4.82*
TRIB3	Tribbles pseudokinase 3	3.45*	3.51*	1.25*	2.74*
CHOP/DDIT3	DNA damage-inducible transcript 3	2.36*	2.04*	1.42*	1.94*
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	2.06*	2.28*	1.46*	1.93*
ATF3	Activating transcription factor 3	2.68*	2.08*	0.82*	1.86*
XBP1	X-box binding protein 1	1.21*	2.22*	1.58*	1.67*
IRE1/ERN1	ER to nucleus signaling 1	1.06*	2.41*	‡	1.16*
ATF4	Activating transcription factor 4	1.16*	1.33*	0.84†	1.11*
GADD34/PPP1R15A	Protein phosphatase 1, regulatory subunit 15A	1.47*	1.84*	‡	1.10*
WARS	Tryptophanyl-tRNA synthetase	1.45*	0.98†	0.88†	1.10*
EDEM1	ER degradation enhancer, mannosidase α-like 1	1.23*	0.82†	0.53†	0.86*
ERDJ4/DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	1.23*	1.25*	‡	0.83*

Log2 ratio >1, P < .01; †log2 ratio <1, P < .01; ‡P > .01.