Characteristics of adult participants with CKD stage 2 or 3
| Characteristic . | eGFR, mL/min/1.73 m2 . | P . | |||
|---|---|---|---|---|---|
| ≥90 . | <90 . | ||||
| No. of patients . | Value* . | No. of patients . | Value* . | ||
| Age, y | 104 | 29.3 (8.8) | 34 | 38.2 (16) | <.001 |
| Female sex, n (%) | 104 | 59 (57) | 34 | 20 (59) | .99 |
| Systolic BP, mmHg | 100 | 109 (13) | 33 | 120 (17) | <.001 |
| Diastolic BP, mmHg | 100 | 65 (8) | 33 | 66 (11) | .61 |
| Prescribed hydroxyurea, n (%) | 104 | 40 (38) | 34 | 16 (47) | .14 |
| On chronic transfusion, n (%) | 104 | 5 (5) | 34 | 5 (15) | .07 |
| PA, n (%) | 104 | 25 (24) | 34 | 16 (47) | .02 |
| ACR, mg/g | 104 | 82.3 (189) | 34 | 173 (272) | .08 |
| Serum creatinine, mg/dL | 81 | 0.57 (0.2) | 34 | 0.94 (0.3) | <.001 |
| Urine osmolality, mOsm/kg | 102 | 379 (68) | 34 | 388 (110) | .58 |
| Blood urea nitrogen, mg/dL | 84 | 7.2 (2.7) | 34 | 15.7 (8.3) | <.001 |
| NAG, U/g | 101 | 3.1 (3) | 34 | 4.6 (5.8) | .07 |
| KIM-1, ng/g | 99 | 481 (445) | 34 | 869 (823) | .004 |
| Hb, g/dL | 93 | 8.8 (1.4) | 34 | 8.7 (1.5) | .52 |
| Reticulocyte count, % | 87 | 12.5 (6) | 27 | 9.2 (4) | .08 |
| Total bilirubin, mg/dL | 87 | 4.1 (3) | 29 | 2.3 (1.3) | .06 |
| LDH, U/L (normal, 135-359 U/L) | 22 | 570 (413) | 11 | 428 (156) | .28 |
| WBC count, ×109/L | 92 | 10.2 (4.1) | 34 | 10.5 (6.3) | .77 |
| Platelet count, ×109/L | 90 | 398 (159) | 34 | 360 (110) | .22 |
| HbF, % | 83 | 9 (8) | 25 | 10 (7.6) | .58 |
| AST, U/L | 77 | 41 (18) | 31 | 48 (24) | .11 |
| ALT, U/L | 47 | 30 (18) | 26 | 26 (14) | .29 |
| Characteristic . | eGFR, mL/min/1.73 m2 . | P . | |||
|---|---|---|---|---|---|
| ≥90 . | <90 . | ||||
| No. of patients . | Value* . | No. of patients . | Value* . | ||
| Age, y | 104 | 29.3 (8.8) | 34 | 38.2 (16) | <.001 |
| Female sex, n (%) | 104 | 59 (57) | 34 | 20 (59) | .99 |
| Systolic BP, mmHg | 100 | 109 (13) | 33 | 120 (17) | <.001 |
| Diastolic BP, mmHg | 100 | 65 (8) | 33 | 66 (11) | .61 |
| Prescribed hydroxyurea, n (%) | 104 | 40 (38) | 34 | 16 (47) | .14 |
| On chronic transfusion, n (%) | 104 | 5 (5) | 34 | 5 (15) | .07 |
| PA, n (%) | 104 | 25 (24) | 34 | 16 (47) | .02 |
| ACR, mg/g | 104 | 82.3 (189) | 34 | 173 (272) | .08 |
| Serum creatinine, mg/dL | 81 | 0.57 (0.2) | 34 | 0.94 (0.3) | <.001 |
| Urine osmolality, mOsm/kg | 102 | 379 (68) | 34 | 388 (110) | .58 |
| Blood urea nitrogen, mg/dL | 84 | 7.2 (2.7) | 34 | 15.7 (8.3) | <.001 |
| NAG, U/g | 101 | 3.1 (3) | 34 | 4.6 (5.8) | .07 |
| KIM-1, ng/g | 99 | 481 (445) | 34 | 869 (823) | .004 |
| Hb, g/dL | 93 | 8.8 (1.4) | 34 | 8.7 (1.5) | .52 |
| Reticulocyte count, % | 87 | 12.5 (6) | 27 | 9.2 (4) | .08 |
| Total bilirubin, mg/dL | 87 | 4.1 (3) | 29 | 2.3 (1.3) | .06 |
| LDH, U/L (normal, 135-359 U/L) | 22 | 570 (413) | 11 | 428 (156) | .28 |
| WBC count, ×109/L | 92 | 10.2 (4.1) | 34 | 10.5 (6.3) | .77 |
| Platelet count, ×109/L | 90 | 398 (159) | 34 | 360 (110) | .22 |
| HbF, % | 83 | 9 (8) | 25 | 10 (7.6) | .58 |
| AST, U/L | 77 | 41 (18) | 31 | 48 (24) | .11 |
| ALT, U/L | 47 | 30 (18) | 26 | 26 (14) | .29 |
Bold font indicates significance.
Values are expressed as mean (SD) unless otherwise noted.