Table 1. Growth inhibition values of... | American Society of Hematology

Table 1.

Growth inhibition values of compounds in engineered BaF3 cell lines

Compound	Parental cells	FLT3-ITD⁺	F691L		Y842C		Y842H		D835V		D835Y
Compound	Parental cells	FLT3-ITD⁺	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance
CCT241736	0.09	0.048	0.083	1.7	0.075	1.6	0.068	1.4	0.089	1.8	0.084	1.7
AC220	1.4	0.0003	0.046	155	0.009	31	0.009	29	0.07	237	0.017	56
Sorafenib	4.3	0.0008	0.44	559	0.11	146	0.13	168	0.66	823	0.17	217

Compound	Parental cells	FLT3-ITD⁺	F691L		Y842C		Y842H		D835V		D835Y
Compound	Parental cells	FLT3-ITD⁺	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance	GI_50, μM	Fold of resistance
CCT241736	0.09	0.048	0.083	1.7	0.075	1.6	0.068	1.4	0.089	1.8	0.084	1.7
AC220	1.4	0.0003	0.046	155	0.009	31	0.009	29	0.07	237	0.017	56
Sorafenib	4.3	0.0008	0.44	559	0.11	146	0.13	168	0.66	823	0.17	217