Incidence rates with 95% CI of hospitalized infections overall and by organism and organ system of HCT vs comparison groups
| . | HCT . | Non-HCT . | DOL . | |||
|---|---|---|---|---|---|---|
| Infection type/ organ system . | Events, n . | Incidence per 1000 PYs (95% CI) . | Events, n . | Incidence per 1000 PYs (95% CI) . | Events, n . | Incidence per 1000 PYs (95% CI) . |
| Infections | ||||||
| All | 661 | 65.4 (60.6-70.5) | 1 234 | 39.6 (37.4-41.8) | 784 | 7.2 (6.7-7.7) |
| Sepsis, any | 207 | 20.4 (17.8-23.4) | 419 | 13.4 (12.2-14.8) | 245 | 2.2 (2.0-2.5) |
| Bacterial | 463 | 45.8 (41.8-50.1) | 830 | 26.6 (24.8-28.5) | 552 | 5.0 (4.6-5.5) |
| Staphylococcus | 110 | 10.9 (9.0-13.1) | 166 | 5.3 (4.6-6.2) | 128 | 1.2 (1.0-1.4) |
| Streptococcus | 74 | 7.3 (5.8-9.2) | 107 | 3.4 (2.8-4.1) | 88 | 0.8 (0.7-1.0) |
| Gram negative | 99 | 9.8 (8.0-11.9) | 206 | 6.6 (5.8-7.6) | 140 | 1.3 (1.1-1.5) |
| Fungal infections | 160 | 15.8 (13.5-18.5) | 256 | 8.2 (7.3-9.3) | 79 | 0.7 (0.6-0.9) |
| Candida | 74 | 7.3 (5.8-9.2) | 152 | 4.9 (4.2-5.7) | 58 | 0.5 (0.4-0.7) |
| Non-Candida | 93 | 9.2 (7.5-11.3) | 109 | 3.5 (2.9-4.2) | 21 | 0.2 (0.1-0.3) |
| Aspergillus | 61 | 6.0 (4.7-7.7) | 71 | 2.3 (1.8-2.9) | 4 | 0.04 (0.01-0.10) |
| Viral | 157 | 15.5 (13.3-18.1) | 328 | 10.5 (9.4-11.7) | 230 | 2.1 (1.8-2.4) |
| Cytomegalovirus | 26 | 2.6 (1.7-3.8) | 42 | 1.3 (1.0-1.8) | 7 | 0.06 (0.03-0.13) |
| H simplex, V zoster | 68 | 6.7 (5.3-8.5) | 124 | 4.0 (3.3-4.7) | 28 | 0.3 (0.2-0.4) |
| Organ system | ||||||
| Nervous/sensory | 26 | 2.6 (1.7-3.8) | 27 | 0.9 (0.6-1.3) | 24 | 0.2 (0.1-0.3) |
| Respiratory | 507 | 50.1 (45.9-54.7) | 812 | 26.0 (24.3-27.9) | 502 | 4.6 (4.2-5.0) |
| Bacterial pneumonia | 104 | 10.3 (8.5-12.4) | 130 | 4.2 (3.5-4.9) | 63 | 0.6 (0.4-0.7) |
| Fungal pneumonia | 51 | 5.0 (3.8-6.6) | 50 | 1.6 (1.2-2.1) | 8 | 0.07 (0.04-0.15) |
| Viral pneumonia | 27 | 2.7 (1.8-3.9) | 32 | 1.0 (0.7-1.4) | 8 | 0.07 (0.04-0.15) |
| Pneumonia, NOS | 245 | 24.2 (21.3-27.4) | 475 | 15.2 (13.9-16.6) | 353 | 3.2 (2.9-3.6) |
| Gastrointestinal | 48 | 4.7 (3.6-6.3) | 92 | 2.9 (2.4-3.6) | 155 | 1.4 (1.2-1.7) |
| Genitourinary | 94 | 9.3 (7.6-11.4) | 354 | 11.3 (10.2-12.6) | 417 | 3.8 (3.5-4.2) |
| Musculoskeletal | 26 | 2.6 (1.7-3.8) | 34 | 1.1 (0.8-1.5) | 44 | 0.4 (0.3-0.5) |
| Skin | 64 | 6.3 (4.9-8.1) | 164 | 5.3 (4.5-6.1) | 254 | 2.3 (2.0-2.6) |
| . | HCT . | Non-HCT . | DOL . | |||
|---|---|---|---|---|---|---|
| Infection type/ organ system . | Events, n . | Incidence per 1000 PYs (95% CI) . | Events, n . | Incidence per 1000 PYs (95% CI) . | Events, n . | Incidence per 1000 PYs (95% CI) . |
| Infections | ||||||
| All | 661 | 65.4 (60.6-70.5) | 1 234 | 39.6 (37.4-41.8) | 784 | 7.2 (6.7-7.7) |
| Sepsis, any | 207 | 20.4 (17.8-23.4) | 419 | 13.4 (12.2-14.8) | 245 | 2.2 (2.0-2.5) |
| Bacterial | 463 | 45.8 (41.8-50.1) | 830 | 26.6 (24.8-28.5) | 552 | 5.0 (4.6-5.5) |
| Staphylococcus | 110 | 10.9 (9.0-13.1) | 166 | 5.3 (4.6-6.2) | 128 | 1.2 (1.0-1.4) |
| Streptococcus | 74 | 7.3 (5.8-9.2) | 107 | 3.4 (2.8-4.1) | 88 | 0.8 (0.7-1.0) |
| Gram negative | 99 | 9.8 (8.0-11.9) | 206 | 6.6 (5.8-7.6) | 140 | 1.3 (1.1-1.5) |
| Fungal infections | 160 | 15.8 (13.5-18.5) | 256 | 8.2 (7.3-9.3) | 79 | 0.7 (0.6-0.9) |
| Candida | 74 | 7.3 (5.8-9.2) | 152 | 4.9 (4.2-5.7) | 58 | 0.5 (0.4-0.7) |
| Non-Candida | 93 | 9.2 (7.5-11.3) | 109 | 3.5 (2.9-4.2) | 21 | 0.2 (0.1-0.3) |
| Aspergillus | 61 | 6.0 (4.7-7.7) | 71 | 2.3 (1.8-2.9) | 4 | 0.04 (0.01-0.10) |
| Viral | 157 | 15.5 (13.3-18.1) | 328 | 10.5 (9.4-11.7) | 230 | 2.1 (1.8-2.4) |
| Cytomegalovirus | 26 | 2.6 (1.7-3.8) | 42 | 1.3 (1.0-1.8) | 7 | 0.06 (0.03-0.13) |
| H simplex, V zoster | 68 | 6.7 (5.3-8.5) | 124 | 4.0 (3.3-4.7) | 28 | 0.3 (0.2-0.4) |
| Organ system | ||||||
| Nervous/sensory | 26 | 2.6 (1.7-3.8) | 27 | 0.9 (0.6-1.3) | 24 | 0.2 (0.1-0.3) |
| Respiratory | 507 | 50.1 (45.9-54.7) | 812 | 26.0 (24.3-27.9) | 502 | 4.6 (4.2-5.0) |
| Bacterial pneumonia | 104 | 10.3 (8.5-12.4) | 130 | 4.2 (3.5-4.9) | 63 | 0.6 (0.4-0.7) |
| Fungal pneumonia | 51 | 5.0 (3.8-6.6) | 50 | 1.6 (1.2-2.1) | 8 | 0.07 (0.04-0.15) |
| Viral pneumonia | 27 | 2.7 (1.8-3.9) | 32 | 1.0 (0.7-1.4) | 8 | 0.07 (0.04-0.15) |
| Pneumonia, NOS | 245 | 24.2 (21.3-27.4) | 475 | 15.2 (13.9-16.6) | 353 | 3.2 (2.9-3.6) |
| Gastrointestinal | 48 | 4.7 (3.6-6.3) | 92 | 2.9 (2.4-3.6) | 155 | 1.4 (1.2-1.7) |
| Genitourinary | 94 | 9.3 (7.6-11.4) | 354 | 11.3 (10.2-12.6) | 417 | 3.8 (3.5-4.2) |
| Musculoskeletal | 26 | 2.6 (1.7-3.8) | 34 | 1.1 (0.8-1.5) | 44 | 0.4 (0.3-0.5) |
| Skin | 64 | 6.3 (4.9-8.1) | 164 | 5.3 (4.5-6.1) | 254 | 2.3 (2.0-2.6) |
NOS, not otherwise specified.