Estimated cumulative incidence of select late effects for AYA patients with AML after ablative HCT
| Late effect . | All patients (N = 826) . | TBI (n = 390) . | Chemotherapy only (n = 436) . | P* . | |||
|---|---|---|---|---|---|---|---|
| No. . | 95% CI . | No. . | 95% CI . | No. . | 95% CI . | ||
| SNs | .73 | ||||||
| 2-y | 0 | 0-1 | 0 | 0-1 | 0 | 0-1 | |
| 5-y | 1 | 0-2 | 1 | 0-2 | 1 | 0-2 | |
| 10-y | 4 | 2-6 | 3 | 1-7 | 4 | 1-8 | |
| AVN | .2 | ||||||
| 2-y | 2 | 1-4 | 3 | 2-5 | 2 | 1-3 | |
| 5-y | 5 | 4-7 | 7 | 4-9 | 4 | 3-7 | |
| 10-y | 8 | 5-10 | 9 | 6-13 | 6 | 4-9 | |
| Cataracts | <.001 | ||||||
| 2-y | 1 | 0-1 | 1 | 0-3 | 0 | 0-1 | |
| 5-y | 5 | 3-7 | 8 | 6-12 | 1 | 0-2 | |
| 10-y | 10 | 7-13 | 15 | 11-19 | 5 | 2-10 | |
| Diabetes mellitus | .21 | ||||||
| 2-y | 1 | 1-2 | 3 | 1-5 | 0 | 0-1 | |
| 5-y | 3 | 2-4 | 4 | 2-6 | 2 | 1-4 | |
| 10-y | 5 | 3-7 | 5 | 3-9 | 4 | 1-8 | |
| Hypothyroidism | .38 | ||||||
| 2-y | 1 | 0-1 | 1 | 0-2 | 0 | 0-1 | |
| 5-y | 2 | 1-3 | 2 | 1-4 | 2 | 1-3 | |
| 10-y | 3 | 2-5 | 4 | 2-7 | 3 | 1-5 | |
| Gonadal dysfunction | .98 | ||||||
| 2-y | 4 | 2-5 | 4 | 2-6 | 3 | 2-5 | |
| 5-y | 7 | 5-9 | 7 | 5-10 | 6 | 4-9 | |
| 10-y | 10 | 8-13 | 10 | 6-13 | 11 | 7-16 | |
| Late effect . | All patients (N = 826) . | TBI (n = 390) . | Chemotherapy only (n = 436) . | P* . | |||
|---|---|---|---|---|---|---|---|
| No. . | 95% CI . | No. . | 95% CI . | No. . | 95% CI . | ||
| SNs | .73 | ||||||
| 2-y | 0 | 0-1 | 0 | 0-1 | 0 | 0-1 | |
| 5-y | 1 | 0-2 | 1 | 0-2 | 1 | 0-2 | |
| 10-y | 4 | 2-6 | 3 | 1-7 | 4 | 1-8 | |
| AVN | .2 | ||||||
| 2-y | 2 | 1-4 | 3 | 2-5 | 2 | 1-3 | |
| 5-y | 5 | 4-7 | 7 | 4-9 | 4 | 3-7 | |
| 10-y | 8 | 5-10 | 9 | 6-13 | 6 | 4-9 | |
| Cataracts | <.001 | ||||||
| 2-y | 1 | 0-1 | 1 | 0-3 | 0 | 0-1 | |
| 5-y | 5 | 3-7 | 8 | 6-12 | 1 | 0-2 | |
| 10-y | 10 | 7-13 | 15 | 11-19 | 5 | 2-10 | |
| Diabetes mellitus | .21 | ||||||
| 2-y | 1 | 1-2 | 3 | 1-5 | 0 | 0-1 | |
| 5-y | 3 | 2-4 | 4 | 2-6 | 2 | 1-4 | |
| 10-y | 5 | 3-7 | 5 | 3-9 | 4 | 1-8 | |
| Hypothyroidism | .38 | ||||||
| 2-y | 1 | 0-1 | 1 | 0-2 | 0 | 0-1 | |
| 5-y | 2 | 1-3 | 2 | 1-4 | 2 | 1-3 | |
| 10-y | 3 | 2-5 | 4 | 2-7 | 3 | 1-5 | |
| Gonadal dysfunction | .98 | ||||||
| 2-y | 4 | 2-5 | 4 | 2-6 | 3 | 2-5 | |
| 5-y | 7 | 5-9 | 7 | 5-10 | 6 | 4-9 | |
| 10-y | 10 | 8-13 | 10 | 6-13 | 11 | 7-16 | |
P value for comparison of TBI and chemotherapy-only MAC regimen.