Table 1. Effective concentration values... | American Society of Hematology

Table 1.

Effective concentration values for JNJ-67571244–mediated cytokine release in a T-cell redirection assay with purified T cells and Kasumi-1 target cells

Cytokine	n	Median EC₂₀, nM	Median EC₅₀, nM	Median EC₉₀, nM
IFN-γ	6	0.048	0.16	1.409
IL-1beta	6	0.013	0.045	0.226
IL-2	4	0.090	0.346	5.282
IL-4	4	0.054	0.078	0.153
IL-8	6	0.015	0.042	0.246
IL-10	6	0.052	0.123	1.271
IL-13	5	0.008	0.034	0.103
TNF-α	6	0.049	0.208	3.530

Cytokine	n	Median EC₂₀, nM	Median EC₅₀, nM	Median EC₉₀, nM
IFN-γ	6	0.048	0.16	1.409
IL-1beta	6	0.013	0.045	0.226
IL-2	4	0.090	0.346	5.282
IL-4	4	0.054	0.078	0.153
IL-8	6	0.015	0.042	0.246
IL-10	6	0.052	0.123	1.271
IL-13	5	0.008	0.034	0.103
TNF-α	6	0.049	0.208	3.530

"n" represents the number of donors out of 6 for which EC values could be determined.

IFN-γ, interferon γ; TNF-α, tumor necrosis factor α.

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