Influence of Prophylactic Measures on Incidence of VOD
| Prophylaxis . | No. With VOD/No. Evaluable (%) . | P Value . |
|---|---|---|
| LMWH | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 4/66 (6.1) | NS |
| UDCA | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 0/31 | NS |
| PGE1 | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 2/22 (9.1) | NS |
| Unfractionated heparin | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 25/335 (7.5) | NS |
| Patients without risk factors | ||
| Heparin | ||
| No6-150 | 1/180 (0.5) | |
| Yes | 1/65 (1.5) | NS |
| Patients with one risk factor | ||
| Heparin | ||
| No6-150 | 6/258 (2.3) | |
| Yes | 10/137 (7.3) | .01 |
| Patients with two risk factors | ||
| Heparin | ||
| No6-150 | 13/173 (7.5) | |
| Yes | 11/115 (9.6) | NS |
| Patients with three or more risk factors | ||
| Heparin | ||
| No6-150 | 11/43 (25.6) | |
| Yes | 3/18 (16.7) | NS |
| Heparin for flushing central lines | ||
| No6-150 | 30/660 (4.5) | |
| Yes | 26/540 (4.8) | NS |
| Dose of heparin used for catheter maintenance | ||
| <1,000 U/d | 13/221 (5.9) | |
| 1,000-5,000 U/d | 11/215 (5.1) | |
| >5,000 U/d | 2/80 (2.5) | NS |
| Prophylaxis . | No. With VOD/No. Evaluable (%) . | P Value . |
|---|---|---|
| LMWH | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 4/66 (6.1) | NS |
| UDCA | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 0/31 | NS |
| PGE1 | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 2/22 (9.1) | NS |
| Unfractionated heparin | ||
| No6-150 | 31/660 (4.7) | |
| Yes | 25/335 (7.5) | NS |
| Patients without risk factors | ||
| Heparin | ||
| No6-150 | 1/180 (0.5) | |
| Yes | 1/65 (1.5) | NS |
| Patients with one risk factor | ||
| Heparin | ||
| No6-150 | 6/258 (2.3) | |
| Yes | 10/137 (7.3) | .01 |
| Patients with two risk factors | ||
| Heparin | ||
| No6-150 | 13/173 (7.5) | |
| Yes | 11/115 (9.6) | NS |
| Patients with three or more risk factors | ||
| Heparin | ||
| No6-150 | 11/43 (25.6) | |
| Yes | 3/18 (16.7) | NS |
| Heparin for flushing central lines | ||
| No6-150 | 30/660 (4.5) | |
| Yes | 26/540 (4.8) | NS |
| Dose of heparin used for catheter maintenance | ||
| <1,000 U/d | 13/221 (5.9) | |
| 1,000-5,000 U/d | 11/215 (5.1) | |
| >5,000 U/d | 2/80 (2.5) | NS |
Abbreviations: LMWH, low molecular weight heparin; UDCA, ursodeoxycholic acid; PGE1, prostaglandin E1; NS, not significant.
Patients with neither systemic prophylaxis nor heparin for flushing central venous lines.