Median (range) Dose and AUC for MTX and MP by Maintenance Cycle
| Cycle . | Dose (mg/m2) . | AUC (μmol · h/L) . | ||
|---|---|---|---|---|
| MTX . | MP . | MTX . | MP . | |
| 1 | 19 | 69 | 3.2 | 1.7 |
| (7.7-22) | (36-94) | (1.2-12) | (0.5-4.8) | |
| 2 | 19 | 68 | 3.3 | 1.6 |
| (2.1-36) | (35-88) | (0.6-7.0) | (0.3-4.6) | |
| 4 | 17 | 60 | 4.0 | 1.1 |
| (6.3-24) | (18-99) | (1.1-8.0) | (0.3-4.1) | |
| 6 | 18 | 66 | 3.4 | 1.8 |
| (6.1-23) | (31-99) | (1.7-9.4) | (0.1-4.2) | |
| Cycle . | Dose (mg/m2) . | AUC (μmol · h/L) . | ||
|---|---|---|---|---|
| MTX . | MP . | MTX . | MP . | |
| 1 | 19 | 69 | 3.2 | 1.7 |
| (7.7-22) | (36-94) | (1.2-12) | (0.5-4.8) | |
| 2 | 19 | 68 | 3.3 | 1.6 |
| (2.1-36) | (35-88) | (0.6-7.0) | (0.3-4.6) | |
| 4 | 17 | 60 | 4.0 | 1.1 |
| (6.3-24) | (18-99) | (1.1-8.0) | (0.3-4.1) | |
| 6 | 18 | 66 | 3.4 | 1.8 |
| (6.1-23) | (31-99) | (1.7-9.4) | (0.1-4.2) | |
Values are the median, with the range in parentheses.