Pharmacokinetic Parameters for Oral MP
| Dose Range (mg/m2) . | n . | . | Cmax (μmol/L) . | AUC (μmol · h/L) . | T1/2 (h) . |
|---|---|---|---|---|---|
| 17.5-99 | 190 | Median | 0.54 | 1.6 | 1.2 |
| Mean* | 0.52 | 1.5 | 1.2 | ||
| Range | 0.040-2.3 | 0.11-8.0 | 0.40-3.3 | ||
| 1st-3rd Quartile† | 0.34-0.86 | 1.0-2.2 | 0.90-1.5 | ||
| 65-85 | 89 | Median | 0.59 | 1.8 | 1.3 |
| Mean* | 0.56 | 1.7 | 1.3 | ||
| Range | 0.13-2.3 | 0.39-4.8 | 0.50-3.3 | ||
| 1st-3rd Quartile† | 0.37-0.89 | 1.2-2.5 | 1.0-1.6 |
| Dose Range (mg/m2) . | n . | . | Cmax (μmol/L) . | AUC (μmol · h/L) . | T1/2 (h) . |
|---|---|---|---|---|---|
| 17.5-99 | 190 | Median | 0.54 | 1.6 | 1.2 |
| Mean* | 0.52 | 1.5 | 1.2 | ||
| Range | 0.040-2.3 | 0.11-8.0 | 0.40-3.3 | ||
| 1st-3rd Quartile† | 0.34-0.86 | 1.0-2.2 | 0.90-1.5 | ||
| 65-85 | 89 | Median | 0.59 | 1.8 | 1.3 |
| Mean* | 0.56 | 1.7 | 1.3 | ||
| Range | 0.13-2.3 | 0.39-4.8 | 0.50-3.3 | ||
| 1st-3rd Quartile† | 0.37-0.89 | 1.2-2.5 | 1.0-1.6 |
The top portion of the table summarizes the parameters derived from all monitored doses (n = 190), and the bottom portion summarizes the same parameters derived only from monitored doses that were within (±) 10 mg/m2 of the standard dose of 75 mg/m2(n = 89).
Geometric mean.
The lower and upper limits of the middle 50% of the data.