Table 1. Pharmacokinetic Parameters for... | American Society of Hematology

Table 1.

Pharmacokinetic Parameters for Oral MTX

Dose Range (mg/m²)	n		C_max (μmol/L)	AUC (μmol · h/L)	T_1/2 (h)
2.1-36	191	Median	1.1	3.5	1.7
		Mean^*	1.1	3.5	1.7
		Range	0.10-4.3	0.63-12	0.70-3.1
		1st-3rd Quartile^†	0.83-1.6	2.6-4.7	1.4-2.0
17.5-22.3	106	Median	1.2	3.6	1.7
		Mean^*	1.2	3.7	1.7
		Range	0.21-3.1	0.63-12	1.1-2.9
		1st-3rd Quartile^†	0.89-1.6	2.8-5.3	1.4-2.0

Dose Range (mg/m²)	n		C_max (μmol/L)	AUC (μmol · h/L)	T_1/2 (h)
2.1-36	191	Median	1.1	3.5	1.7
		Mean^*	1.1	3.5	1.7
		Range	0.10-4.3	0.63-12	0.70-3.1
		1st-3rd Quartile^†	0.83-1.6	2.6-4.7	1.4-2.0
17.5-22.3	106	Median	1.2	3.6	1.7
		Mean^*	1.2	3.7	1.7
		Range	0.21-3.1	0.63-12	1.1-2.9
		1st-3rd Quartile^†	0.89-1.6	2.8-5.3	1.4-2.0

The top portion of the table summarizes the parameters derived from all monitored doses (n = 191), and the bottom portion summarizes the same parameters derived only from monitored doses that were within (±) 2.5 mg/m² of the standard dose of 20 mg/m² (n = 106).

Geometric mean.

†

The lower and upper limits of the middle 50% of the data.

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