Hematologic Data and Major Lipid Antioxidants in Plasma From β-Thalassemia Intermedia Patients and Controls
| . | Controls n = 35 . | β-Thalassemia Patients n = 35 . | P . |
|---|---|---|---|
| Ferritin (ng/mL) | 80 ± 10 | 687 ± 343 | <.001 |
| Bilirubin (mg/dL) | 0.68 ± 0.16 | 2.7 ± 1.36 | <.001 |
| Total cholesterol (mmol/L) | 5.53 ± 0.18 | 2.78 ± 0.51 | <.001 |
| HDL cholesterol (mmol/L) | 1.42 ± 0.15 | 0.85 ± 0.16 | <.001 |
| LDL cholesterol (mmol/L) | 3.62 ± 0.41 | 1.42 ± 0.20 | <.001 |
| Triglycerides (mmol/L) | 1.17 ± 0.27 | 1.22 ± 0.30 | .466 |
| Vitamin E (μmol/L) | 18.9 ± 4.0 | 9.26 ± 2.94 | <.001 |
| Vitamin A (μmol/L) | 1.79 ± 0.13 | 1.43 ± 0.7 | .004 |
| Lipid-corrected vitamin E* | 2.82 ± 0.55 | 2.31 ± 0.99 | .010 |
| Lipid-corrected vitamin A* | 0.26 ± 0.07 | 0.30 ± 0.1 | .057 |
| . | Controls n = 35 . | β-Thalassemia Patients n = 35 . | P . |
|---|---|---|---|
| Ferritin (ng/mL) | 80 ± 10 | 687 ± 343 | <.001 |
| Bilirubin (mg/dL) | 0.68 ± 0.16 | 2.7 ± 1.36 | <.001 |
| Total cholesterol (mmol/L) | 5.53 ± 0.18 | 2.78 ± 0.51 | <.001 |
| HDL cholesterol (mmol/L) | 1.42 ± 0.15 | 0.85 ± 0.16 | <.001 |
| LDL cholesterol (mmol/L) | 3.62 ± 0.41 | 1.42 ± 0.20 | <.001 |
| Triglycerides (mmol/L) | 1.17 ± 0.27 | 1.22 ± 0.30 | .466 |
| Vitamin E (μmol/L) | 18.9 ± 4.0 | 9.26 ± 2.94 | <.001 |
| Vitamin A (μmol/L) | 1.79 ± 0.13 | 1.43 ± 0.7 | .004 |
| Lipid-corrected vitamin E* | 2.82 ± 0.55 | 2.31 ± 0.99 | .010 |
| Lipid-corrected vitamin A* | 0.26 ± 0.07 | 0.30 ± 0.1 | .057 |
Results are expressed as mean ± SD. P values were determined by the Student’s t-test. Hematologic data from thalassemia patients are the mean of the values from each patient during 1 year of observation. LDL cholesterol was calculated by the Friedwald formula: LDL cholesterol (mmol/L) = Total cholesterol (mmol/L) − [HDL cholesterol (mmol/L) + (0.42 × triglycerides (mmol/L)]).
Lipid-corrected -vitamin E or -vitamin A refers to the ratio vitamin E or vitamin A (μmol/L)/[total cholesterol + triglycerides (mmol/L)]. Values are obtained from determinations performed in duplicate on blood samples from different subjects. Each thalassemia patient contributed the mean of two values measured during 1 year of observation.