Disease Characteristics of Murine CML
| Mouse . | Latency (wks) . | WBC . | Differential Count . | Spleen Weight (g) . |
|---|---|---|---|---|
| Grb2 | − | 15 | 45P/50L/5M | 0.2 |
| H20 | 4 | 75 | 84P/5L/3M/6NR | 0.6 |
| H21 | 4 | 100 | 73P/11L/1M/11NR | 0.8 |
| H22 | 3 | 77 | 69P/7L/3M/9NR | 0.6 |
| H23 | 4 | 77 | 80P/7L/2M/1NR | 0.6 |
| H24 | 3 | 36 | 51P/9L/1M/36NR/3Blasts | 0.7 |
| H25 | 4 | 265 | 86P/2L/1M/11NR | 0.9 |
| H26 | 4 | 250 | 90P/3L/2M/1NR | 0.75 |
| H27 | 3 | 53 | ND | 0.6 |
| H28 | 4 | 220 | 79P/13L/3M/5NR | 0.8 |
| H29 | 3 | 200 | 76P/4L/20NR | 0.85 |
| Mouse . | Latency (wks) . | WBC . | Differential Count . | Spleen Weight (g) . |
|---|---|---|---|---|
| Grb2 | − | 15 | 45P/50L/5M | 0.2 |
| H20 | 4 | 75 | 84P/5L/3M/6NR | 0.6 |
| H21 | 4 | 100 | 73P/11L/1M/11NR | 0.8 |
| H22 | 3 | 77 | 69P/7L/3M/9NR | 0.6 |
| H23 | 4 | 77 | 80P/7L/2M/1NR | 0.6 |
| H24 | 3 | 36 | 51P/9L/1M/36NR/3Blasts | 0.7 |
| H25 | 4 | 265 | 86P/2L/1M/11NR | 0.9 |
| H26 | 4 | 250 | 90P/3L/2M/1NR | 0.75 |
| H27 | 3 | 53 | ND | 0.6 |
| H28 | 4 | 220 | 79P/13L/3M/5NR | 0.8 |
| H29 | 3 | 200 | 76P/4L/20NR | 0.85 |
Characteristics of the P210-induced myeloproliferative disease in one transplant experiment. Disease was induced by transduction with MSCV 210 (see Table 1). Grb2 is a mouse that received MSCV Grb2, which only expresses grb2. This mouse (as did all MSCV Grb2 mice) remained healthy for the entire 9-month observation period. WBC count is 106 cells/mL. For the differential counts, P indicates polymorphonuclear granulocytes, L indicates lymphocytes, M indicates monocytes, NR indicates nucleated red blood cells, and ND indicates not determined.