Summary of murine P210 bcr/abl bone marrow transfer experiments
| Construct . | No. of Independent, Experiments . | No. of Evaluable Mice . | No. of Mice With Murine CML . | Latency (d) . | WBC Range (× 106 cells/mL) . | Spleen Weight Range in Grams . | % With Pulmonary Involvement . | % With Macrophage Foci . |
|---|---|---|---|---|---|---|---|---|
| MSCV 210 | 1 | 11 | 11 | 21-31 | 36-265 | 0.6-0.9 | 100 | 91 |
| MSCV 210/grb2 | 2 | 19 | 19 | 19-26 | 50-160 | 0.6-0.9 | 100 | 47 |
| Mig 210 | 2 | 10 | 10 | 16-19 | 60-390 | 0.6-0.75 | 100 | 20 |
| Construct . | No. of Independent, Experiments . | No. of Evaluable Mice . | No. of Mice With Murine CML . | Latency (d) . | WBC Range (× 106 cells/mL) . | Spleen Weight Range in Grams . | % With Pulmonary Involvement . | % With Macrophage Foci . |
|---|---|---|---|---|---|---|---|---|
| MSCV 210 | 1 | 11 | 11 | 21-31 | 36-265 | 0.6-0.9 | 100 | 91 |
| MSCV 210/grb2 | 2 | 19 | 19 | 19-26 | 50-160 | 0.6-0.9 | 100 | 47 |
| Mig 210 | 2 | 10 | 10 | 16-19 | 60-390 | 0.6-0.75 | 100 | 20 |
The results summarize five independent experiments. For MSCV 210/grb2, 23 mice were reconstituted; however, 4 mice died before analysis and tissue degradation precluded diagnosis. Latency is defined as either time to death or time to onset of terminal symptoms consisting of cachexia, decreased activity, and hunched posture with tachypnea. For control mice transduced with either MigR1 or MSCV grb2, the WBC ranged from 5 to 15 × 106/mL cells during this period and spleen weights were 0.1 to 0.25 grams.