Linkage of Particular Loci With B-1 Cell Proliferation in the Backcross Progeny
| Chr* . | Locus . | Distance† . | Direction‡ . | 8 Months2-153 . | 16 Months2-153 . | Lod2-155 . | |||
|---|---|---|---|---|---|---|---|---|---|
| χ2 . | P . | χ2 . | P . | 8 Months . | 16 Months . | ||||
| 13 | D13MIT80 | 15.8 | NB > BB | 1.8 | 1.1 | ||||
| D13MIT136 | 4.9 | NB > BB | 9.48 | .0021 | 6.04 | .014 | 4.0 | 2.0 | |
| D13MIT61 | 11.3 | NB > BB | 8.38 | .0038 | 7.44 | .0064 | 3.5 | 1.7 | |
| D13MIT13 | 19.0 | NB > BB | 8.38 | .0038 | 14.42 | .0001 | 3.2 | 3.0 | |
| D13MIT126 | 15.1 | NB > BB | 8.08 | .0045 | 1.5 | 1.6 | |||
| D13MIT47 | 11.4 | NB > BB | 1.3 | ||||||
| D13MIT31 | — | ||||||||
| 17 | D17MIT222 | 10.6 | NB > BB | 6.02 | .014 | 8.44 | .0037 | 2.2 | 1.3 |
| D17MIT167 | 8.1 | NB > BB | 3.41 | .065 | 1.5 | ||||
| D17MIT137 | 6.6 | NB > BB | 2.78 | .096 | 1.4 | ||||
| D17MIT67 | 3.5 | NB > BB | 6.79 | .0092 | 1.2 | ||||
| D17MIT9 | 6.4 | NB > BB | 6.79 | .0092 | |||||
| D17MIT87 | 11.8 | ||||||||
| D17MIT159 | 4.2 | ||||||||
| D17MIT218 | 9.8 | ||||||||
| D17MIT2 | — | ||||||||
| Chr* . | Locus . | Distance† . | Direction‡ . | 8 Months2-153 . | 16 Months2-153 . | Lod2-155 . | |||
|---|---|---|---|---|---|---|---|---|---|
| χ2 . | P . | χ2 . | P . | 8 Months . | 16 Months . | ||||
| 13 | D13MIT80 | 15.8 | NB > BB | 1.8 | 1.1 | ||||
| D13MIT136 | 4.9 | NB > BB | 9.48 | .0021 | 6.04 | .014 | 4.0 | 2.0 | |
| D13MIT61 | 11.3 | NB > BB | 8.38 | .0038 | 7.44 | .0064 | 3.5 | 1.7 | |
| D13MIT13 | 19.0 | NB > BB | 8.38 | .0038 | 14.42 | .0001 | 3.2 | 3.0 | |
| D13MIT126 | 15.1 | NB > BB | 8.08 | .0045 | 1.5 | 1.6 | |||
| D13MIT47 | 11.4 | NB > BB | 1.3 | ||||||
| D13MIT31 | — | ||||||||
| 17 | D17MIT222 | 10.6 | NB > BB | 6.02 | .014 | 8.44 | .0037 | 2.2 | 1.3 |
| D17MIT167 | 8.1 | NB > BB | 3.41 | .065 | 1.5 | ||||
| D17MIT137 | 6.6 | NB > BB | 2.78 | .096 | 1.4 | ||||
| D17MIT67 | 3.5 | NB > BB | 6.79 | .0092 | 1.2 | ||||
| D17MIT9 | 6.4 | NB > BB | 6.79 | .0092 | |||||
| D17MIT87 | 11.8 | ||||||||
| D17MIT159 | 4.2 | ||||||||
| D17MIT218 | 9.8 | ||||||||
| D17MIT2 | — | ||||||||
Chromosome number.
Distance in centiMorgans (Kosambi function) between two consecutive markers as calculated by MAPMAKER/EXP. Markers are arranged from centromeric to teromeric.
NB, heterozygous loci of NZW and B10.NZW; BB, homozygous loci of B10.NZW. An inequality NB > BB indicates that the phenotype is biased to progeny genotyped as NB.
Peripheral B-1 cell frequencies are considered as increased if exceeding 5% in mice 8 months of age or 10% in mice 16 months of age.
Log of the likelihood ratio (lod) scores are analyzed by MAPMAKER/QTL. Lod scores only greater than 1 are indicated.