Nonpharmacologic methods to prevent graft-versus-host disease (GVHD).
| Function . | Clinical Technique . |
|---|---|
| Abbreviations: GVHD, graft-versus-host disease; GVL, graft-versus-leukemia; NK, natural killer; KIR, killer immunoglobulin-like receptor; APC, antigen-presenting cells. | |
| Allo-activated T cells can be distinguished from quiescent and physical properties | Selective depletion or anergy of alloreactive T cells by phenotype cells. |
| T cells recognize lineage-restricted antigens on leukemia cells. | Selective depletion of T-cell depletion with preservation of GVL. Adoptive transfer of leukemia-specific and virus-specific T-cell clones. |
| Naïve not memory T cells contain alloresponding T cells. | Transplantation of memory cells from donor boosted with leukemia-specific antigen vaccines. |
| T-helper 2 and T-cytotoxic 2 lymphocytes exert GVL not GVHD. | Generation of Th2/Tc2 T cells for transplantation. |
| GVL effects can be achieved in a short timeframe. | Suicide gene insertion into T cells allows switch-off of GVHD once GVL has occurred. |
| CD4/CD25+ T regulatory cells suppress alloresponses (effect on GVL uncertain). | Select and transfuse of T regulatory cells to prevent GVHD. |
| NK cells are cytotoxic to leukemia and viral infected cells but do not cause GVHD. NK cells eliminate host APC that initiate GVHD. | Select NK KIR-ligand mismatched transplants. |
| Function . | Clinical Technique . |
|---|---|
| Abbreviations: GVHD, graft-versus-host disease; GVL, graft-versus-leukemia; NK, natural killer; KIR, killer immunoglobulin-like receptor; APC, antigen-presenting cells. | |
| Allo-activated T cells can be distinguished from quiescent and physical properties | Selective depletion or anergy of alloreactive T cells by phenotype cells. |
| T cells recognize lineage-restricted antigens on leukemia cells. | Selective depletion of T-cell depletion with preservation of GVL. Adoptive transfer of leukemia-specific and virus-specific T-cell clones. |
| Naïve not memory T cells contain alloresponding T cells. | Transplantation of memory cells from donor boosted with leukemia-specific antigen vaccines. |
| T-helper 2 and T-cytotoxic 2 lymphocytes exert GVL not GVHD. | Generation of Th2/Tc2 T cells for transplantation. |
| GVL effects can be achieved in a short timeframe. | Suicide gene insertion into T cells allows switch-off of GVHD once GVL has occurred. |
| CD4/CD25+ T regulatory cells suppress alloresponses (effect on GVL uncertain). | Select and transfuse of T regulatory cells to prevent GVHD. |
| NK cells are cytotoxic to leukemia and viral infected cells but do not cause GVHD. NK cells eliminate host APC that initiate GVHD. | Select NK KIR-ligand mismatched transplants. |