Cytokine genes, chromosome location and polymorphism/ microsatellites.
| Cytokine Gene . | Chromosome Location . | Polymorphism/Microsatellite . | Ref. No. . |
|---|---|---|---|
| Abbreviations: TNF, tumor necrosis factor; IL, interleukin; IFN, interferon; TGF, transforming growth factor. | |||
| TNFα | Chromosome 6 Class III region of MHC | G/A substitution at position −308 (TNF 2 allele) C/A substitute TNF −863 C/T substitution TNF −857 TNF d3 Microsatellite | 4, 18, 19, 20 |
| TNF receptor (TNFR I, TNFRII) | Chromosome 12p13 | TNR R.1 (p55) polymorphisms TNF R.11\(p75) polymorphisms M/R substitution at −196 | 20, 21, 22 |
| IL-10 | Chromosome 1 | G/A substitution at −1082 C/T substitution at −819 C/A substitution at −592 C/A substitution −1064 (CA) microsatellite at −1064 | 4, 19, 23, 24, 25, 26 |
| IL-6 | Chromosome 7p 21 | G/C substitution at −174 | 25, 26, 27 |
| IFN-γ | Chromosome 12q24.12 | (CA) repeat microsatellite | 25 |
| IL-1 | Chromosome 2 | C/T polymorphism at −889 C/T polymorphism at −511 | 28, 29, 30 |
| IL-1 receptor antagonist (IL-1Ra) alpha | Variable number tandem repeat intron 2 | ||
| TGFβ1 TGFβ receptor 11 (TNFβII) | Chromosome 19q13 Chromosome 3p22 | C/T substitution at −509 C/T substitution at −1167 | 31, 32 |
| Cytokine Gene . | Chromosome Location . | Polymorphism/Microsatellite . | Ref. No. . |
|---|---|---|---|
| Abbreviations: TNF, tumor necrosis factor; IL, interleukin; IFN, interferon; TGF, transforming growth factor. | |||
| TNFα | Chromosome 6 Class III region of MHC | G/A substitution at position −308 (TNF 2 allele) C/A substitute TNF −863 C/T substitution TNF −857 TNF d3 Microsatellite | 4, 18, 19, 20 |
| TNF receptor (TNFR I, TNFRII) | Chromosome 12p13 | TNR R.1 (p55) polymorphisms TNF R.11\(p75) polymorphisms M/R substitution at −196 | 20, 21, 22 |
| IL-10 | Chromosome 1 | G/A substitution at −1082 C/T substitution at −819 C/A substitution at −592 C/A substitution −1064 (CA) microsatellite at −1064 | 4, 19, 23, 24, 25, 26 |
| IL-6 | Chromosome 7p 21 | G/C substitution at −174 | 25, 26, 27 |
| IFN-γ | Chromosome 12q24.12 | (CA) repeat microsatellite | 25 |
| IL-1 | Chromosome 2 | C/T polymorphism at −889 C/T polymorphism at −511 | 28, 29, 30 |
| IL-1 receptor antagonist (IL-1Ra) alpha | Variable number tandem repeat intron 2 | ||
| TGFβ1 TGFβ receptor 11 (TNFβII) | Chromosome 19q13 Chromosome 3p22 | C/T substitution at −509 C/T substitution at −1167 | 31, 32 |