Conventional chemotherapy versus high-dose therapy. Results of randomized studies.
| . | . | . | . | CR Rate, % . | Median EFS, mos . | Median Median OS, mos . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | N . | Age . | Follow-up . | CC . | HDT . | CC . | HDT . | CC . | HDT . |
| Abbreviations: CC, conventional chemotherapy; CR, complete remission; EFS, event-free survival; HDT, high-dose therapy; IFM, Intergroupe Français du Myélome; MAG, Myelome Auto Greffe; MMSG, Multiple Myeloma Study Group; NE, not evaluated; NR, not reached; OS, overall survival. | |||||||||
| IFM 90 (1) | 200 | <65 | 7 yrs | 5 | 22 | 18 | 28 | 44 | 57 |
| MAG 91 (2) | 190 | 55-65 | 56 mos | NE | NE | 19 | 24 | 50 | 55 |
| Pethema (3) | 164 | Median 56 | 42 mos | 11 | 30 | 33 | 42 | 64 | 72 |
| Italian MMSG (4) | 195 | <70 | 2 yrs | 6 | 28 | 21 | 34 | NR | NR |
| . | . | . | . | CR Rate, % . | Median EFS, mos . | Median Median OS, mos . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | N . | Age . | Follow-up . | CC . | HDT . | CC . | HDT . | CC . | HDT . |
| Abbreviations: CC, conventional chemotherapy; CR, complete remission; EFS, event-free survival; HDT, high-dose therapy; IFM, Intergroupe Français du Myélome; MAG, Myelome Auto Greffe; MMSG, Multiple Myeloma Study Group; NE, not evaluated; NR, not reached; OS, overall survival. | |||||||||
| IFM 90 (1) | 200 | <65 | 7 yrs | 5 | 22 | 18 | 28 | 44 | 57 |
| MAG 91 (2) | 190 | 55-65 | 56 mos | NE | NE | 19 | 24 | 50 | 55 |
| Pethema (3) | 164 | Median 56 | 42 mos | 11 | 30 | 33 | 42 | 64 | 72 |
| Italian MMSG (4) | 195 | <70 | 2 yrs | 6 | 28 | 21 | 34 | NR | NR |