Available clotting factor concentrates. Plasma-derived except where noted as recombinant. Not all these concentrates are available in all countries.
| Concentrate . | Comments . |
|---|---|
| *See text for more complete discussion of these products. | |
| *Factor VIII | Intermediate and high purity preparations available |
| *Factor VIII, recombinant | Stabilized in albumin or sucrose; full-length or B-domain deleted |
| *Factor VIII, porcine | For factor VIII inhibitor patients |
| Prothrombin complex (PCC) | Calibrated in factor IX units; variable concentrations II, X, and VII |
| *Factor IX | High purity, for hemophilia B |
| *Factor IX, recombinant | Full length, stabilized in sucrose |
| *Activated prothrombin complex (APCC) | For factor VIII or IX inhibitor patients |
| *Factor VIIa, recombinant (rFVIIa) | For factor VIII or IX inhibitor patients; may develop wider indications |
| *von Willebrand factor (vWF) | VIII/VWF or single component VWF (see Table 6) |
| *Factor XI | Co-purified with AT III; heparin added |
| Factor VII | For congenital VII deficiency; factor VIIa is an alternative |
| Factor XIII | Suitable for long-term prophylaxis |
| Fibrinogen | Virally inactivated alternative to cryoprecipitate |
| Concentrate . | Comments . |
|---|---|
| *See text for more complete discussion of these products. | |
| *Factor VIII | Intermediate and high purity preparations available |
| *Factor VIII, recombinant | Stabilized in albumin or sucrose; full-length or B-domain deleted |
| *Factor VIII, porcine | For factor VIII inhibitor patients |
| Prothrombin complex (PCC) | Calibrated in factor IX units; variable concentrations II, X, and VII |
| *Factor IX | High purity, for hemophilia B |
| *Factor IX, recombinant | Full length, stabilized in sucrose |
| *Activated prothrombin complex (APCC) | For factor VIII or IX inhibitor patients |
| *Factor VIIa, recombinant (rFVIIa) | For factor VIII or IX inhibitor patients; may develop wider indications |
| *von Willebrand factor (vWF) | VIII/VWF or single component VWF (see Table 6) |
| *Factor XI | Co-purified with AT III; heparin added |
| Factor VII | For congenital VII deficiency; factor VIIa is an alternative |
| Factor XIII | Suitable for long-term prophylaxis |
| Fibrinogen | Virally inactivated alternative to cryoprecipitate |