Combination IV treatment of refractory immune thrombocytopenic purpura.
| Abbreviations: IVIG VCR, intravenous gammaglobulin vincristine |
| 1. MEDS/DOSES: IVIG 1 g/kg, Solumedrol 1 g (30 mg/kg), VCR 0.03 mg/kg (1-1.5 mg IVP), and/or Anti-D 75 μg/kg |
| 2. > 70% acute response rate in largely refractory patients i.e. no response to IVIG alone |
| 3. ORAL MAINTENANCE MEDS/DOSES: Danazol 600-800 mg/kg and Imuran 2 mg/kg (cyclosporin, dapsone, Cellcept, cyclophosphamide can be substituted if needed) |
| 4. 3-4 month response rate > 70% of responders, long-term plan to taper to low dose danazol and/or imuran—long-term response rate uncertain |
| Abbreviations: IVIG VCR, intravenous gammaglobulin vincristine |
| 1. MEDS/DOSES: IVIG 1 g/kg, Solumedrol 1 g (30 mg/kg), VCR 0.03 mg/kg (1-1.5 mg IVP), and/or Anti-D 75 μg/kg |
| 2. > 70% acute response rate in largely refractory patients i.e. no response to IVIG alone |
| 3. ORAL MAINTENANCE MEDS/DOSES: Danazol 600-800 mg/kg and Imuran 2 mg/kg (cyclosporin, dapsone, Cellcept, cyclophosphamide can be substituted if needed) |
| 4. 3-4 month response rate > 70% of responders, long-term plan to taper to low dose danazol and/or imuran—long-term response rate uncertain |