Potential predispositions and etiologies of immune thrombocytopenic purpura (ITP).
| Predispositions . |
|---|
| 1. hypogammaglobulinemia: combined variable immunodeficiency (CVI), severe combined immunodeficiency disease (SCID), IgA and IgG2 deficiency, but not x-linked agammaglobulinemia (XLA) |
| 2. deficiency of classical pathway of complement components, C4, C2 |
| 3. ? certain HLA types, e.g. B8DR3 |
| 4. abnormalities of CD95 (Fas pathway) |
| 5. ? other failure of autoimmune lymphocytes |
| 6. ? certain Fc receptor polymorphisms |
| Predispositions . |
|---|
| 1. hypogammaglobulinemia: combined variable immunodeficiency (CVI), severe combined immunodeficiency disease (SCID), IgA and IgG2 deficiency, but not x-linked agammaglobulinemia (XLA) |
| 2. deficiency of classical pathway of complement components, C4, C2 |
| 3. ? certain HLA types, e.g. B8DR3 |
| 4. abnormalities of CD95 (Fas pathway) |
| 5. ? other failure of autoimmune lymphocytes |
| 6. ? certain Fc receptor polymorphisms |
| Etiologies . |
|---|
| 1. Persistent antigen exposure |
| 2. ? selection of certain heavy chain genes in antibody production |
| 3. unknown tendency to develop autoimmunity: systemic lupus erythematosus (SLE), Evans syndrome |
| 4. abnormal antigen presentation, e.g. in lymphoproliferative states such as chronic lymphocytic leukemia (CLL) |
| 5. persistent infections: see Table 4 |
| Etiologies . |
|---|
| 1. Persistent antigen exposure |
| 2. ? selection of certain heavy chain genes in antibody production |
| 3. unknown tendency to develop autoimmunity: systemic lupus erythematosus (SLE), Evans syndrome |
| 4. abnormal antigen presentation, e.g. in lymphoproliferative states such as chronic lymphocytic leukemia (CLL) |
| 5. persistent infections: see Table 4 |