Effects of CLT or CDA treatment on hematologic parameters in 4.1-/- and 4.2-/- mice
. | Baseline . | CLT or CDA . | P . |
|---|---|---|---|
| 4.1-/-, CLT 80 mg/kg bid | |||
| No. animals | 14 | 5 | |
| Hct, % | 34.0 ± 4.0 | 33.0 ± 4.6 | — |
| Hb, g/dL | 11.5 ± 0.5 | 10.9 ± 0.4 | — |
| CHCM, g/dL | 32.9 ± 0.5 | 34.5 ± 0.8 | < .05 |
| HDW, g/dL | 3.15 ± 0.1 | 4.2 ± 0.2 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 6.03 ± 2.6 | 14.6 ± 0.9 | < .05 |
| CHCM above 37 and MCV below 25 | 1.11 ± 0.4 | 2.05 ± 0.2 | < .05 |
| Reticulocytes, % | 19.5 ± 1.8 | 28.2 ± 8 | < .05 |
| 4.1-/-, CDA 100 mg/kg bid | |||
| No. animals | 6 | 4 | |
| Hct, % | 36.9 ± 3.3 | 29.2 ± 2.3 | < .05 |
| Hb, g/dL | 12.1 ± 1.0 | 9.7 ± 1.1 | < .05 |
| CHCM, g/dL | 31.5 ± 0.2 | 33.0 ± 0.9 | < .05 |
| HDW, g/dL | 3.13 ± 0.08 | 3.7 ± 0.3 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 1.65 ± 0.2 | 7.2 ± 2.5 | < .05 |
| CHCM above 37 and MCV below 25 | 0.65 ± 0.05 | 1.5 ± 0.4 | < .05 |
| Reticulocytes, % | 22.4 ± 3.9 | 26.9 ± 4.1 | — |
| 4.2-/-, CLT 80 mg/kg bid | |||
| No. animals | 6 | 6 | |
| Hct, % | 39.7 ± 1.3 | 39.2 ± 0.8 | — |
| Hb, g/dL | 14.3 ± 1.0 | 13.7 ± 1.2 | — |
| CHCM, g/dL | 33.3 ± 0.2 | 33.0 ± 0.5 | — |
| HDW, g/dL | 2.79 ± 0.16 | 4.21 ± 0.5 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 6.7 ± 2.7 | 12.4 ± 4.2 | < .05 |
| CHCM above 37 and MCV below 25 | 0.11 ± 0.07 | 0.2 ± 0.1 | — |
| Reticulocytes, % | 6.58 ± 1.6 | 7.6 ± 2.5 | — |
. | Baseline . | CLT or CDA . | P . |
|---|---|---|---|
| 4.1-/-, CLT 80 mg/kg bid | |||
| No. animals | 14 | 5 | |
| Hct, % | 34.0 ± 4.0 | 33.0 ± 4.6 | — |
| Hb, g/dL | 11.5 ± 0.5 | 10.9 ± 0.4 | — |
| CHCM, g/dL | 32.9 ± 0.5 | 34.5 ± 0.8 | < .05 |
| HDW, g/dL | 3.15 ± 0.1 | 4.2 ± 0.2 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 6.03 ± 2.6 | 14.6 ± 0.9 | < .05 |
| CHCM above 37 and MCV below 25 | 1.11 ± 0.4 | 2.05 ± 0.2 | < .05 |
| Reticulocytes, % | 19.5 ± 1.8 | 28.2 ± 8 | < .05 |
| 4.1-/-, CDA 100 mg/kg bid | |||
| No. animals | 6 | 4 | |
| Hct, % | 36.9 ± 3.3 | 29.2 ± 2.3 | < .05 |
| Hb, g/dL | 12.1 ± 1.0 | 9.7 ± 1.1 | < .05 |
| CHCM, g/dL | 31.5 ± 0.2 | 33.0 ± 0.9 | < .05 |
| HDW, g/dL | 3.13 ± 0.08 | 3.7 ± 0.3 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 1.65 ± 0.2 | 7.2 ± 2.5 | < .05 |
| CHCM above 37 and MCV below 25 | 0.65 ± 0.05 | 1.5 ± 0.4 | < .05 |
| Reticulocytes, % | 22.4 ± 3.9 | 26.9 ± 4.1 | — |
| 4.2-/-, CLT 80 mg/kg bid | |||
| No. animals | 6 | 6 | |
| Hct, % | 39.7 ± 1.3 | 39.2 ± 0.8 | — |
| Hb, g/dL | 14.3 ± 1.0 | 13.7 ± 1.2 | — |
| CHCM, g/dL | 33.3 ± 0.2 | 33.0 ± 0.5 | — |
| HDW, g/dL | 2.79 ± 0.16 | 4.21 ± 0.5 | < .05 |
| CHCM above 37 and MCV equal to 25-75 | 6.7 ± 2.7 | 12.4 ± 4.2 | < .05 |
| CHCM above 37 and MCV below 25 | 0.11 ± 0.07 | 0.2 ± 0.1 | — |
| Reticulocytes, % | 6.58 ± 1.6 | 7.6 ± 2.5 | — |
Data are presented as mean ± SD.
— indicates not significant; bid, twice a day; Hct, hematocrit; Hb, hemoglobin.