Table 5. Direct recognition and lysis of... | American Society of Hematology

Table 5.

Direct recognition and lysis of leukemia cells by NIK-1: experiment 2

Target cells	% cytotoxicity, at 10:1 E/T ratio
C2F8 cells
No anti-HLA mAb	27.6
With anti-HLA-DR mAb	28.0
With anti-HLA-DQ mAb	30.3
With anti-HLA-DP mAb	3.1
Freshly isolated leukemia cells
From donor no. 1 (AML M1)
No anti-HLA mAb	45.1
With anti-HLA-DR mAb	43.2
With anti-HLA-DQ mAb	41.6
With anti-HLA-DP mAb	5.6
From donor no. 2 (AML M2)
No anti-HLA mAb	33.6
With anti-HLA-DR mAb	31.7
With anti-HLA-DQ mAb	35.1
With anti-HLA-DP mAb	5.6

Target cells	% cytotoxicity, at 10:1 E/T ratio
C2F8 cells
No anti-HLA mAb	27.6
With anti-HLA-DR mAb	28.0
With anti-HLA-DQ mAb	30.3
With anti-HLA-DP mAb	3.1
Freshly isolated leukemia cells
From donor no. 1 (AML M1)
No anti-HLA mAb	45.1
With anti-HLA-DR mAb	43.2
With anti-HLA-DQ mAb	41.6
With anti-HLA-DP mAb	5.6
From donor no. 2 (AML M2)
No anti-HLA mAb	33.6
With anti-HLA-DR mAb	31.7
With anti-HLA-DQ mAb	35.1
With anti-HLA-DP mAb	5.6

Cytotoxicity of NIK-1 against leukemia cell line and freshly isolated leukemia cells in the presence or absence of anti-HLA-DR, anti-HLA-DQ, or anti-HLA-DP mAb.

E/T ratio indicates effector-target ratio.

View Large

This Feature Is Available To Subscribers Only