Platelet aggregate size distribution at 1300 s–1
Mouse genotype . | Aggregates containing 1 to 2 platelets, % . | Aggregates containing 3 to 10 platelets, % . | Aggregates containing 11 to 30 platelets, % . | Aggregates containing 31 to 50 platelets, % . |
|---|---|---|---|---|
| Wild type | 60.3 ± 2.8 | 21.2 ± 2.3 | 13.7 ± 0.6 | 4.8 ± 0.6 |
| α2β1-/- | 72.8 ± 3.3 | 24.3 ± 2.8 | 2.8 ± 0.9 | 0.1 ± 0.1 |
| GPVI-FcRγ-/- | 97.0 ± 0.4 | 3.0 ± 0.4 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| GPVI-FcRγ-/-/α2β1-/- | 96.8 ± 1.5 | 3.2 ± 1.5 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| SLP-76-/- | 94.7 ± 1.9 | 5.1 ± 1.8 | 0.1 ± 0.1 | 0.1 ± 0.0 |
| LAT-/- | 75.2 ± 4.1 | 19.4 ± 2.8 | 4.8 ± 1.4 | 0.6 ± 0.2 |
| Low-GPVI | 92.7 ± 1.9 | 6.9 ± 1.8 | 0.3 ± 0.1 | 0.0 ± 0.0 |
Mouse genotype . | Aggregates containing 1 to 2 platelets, % . | Aggregates containing 3 to 10 platelets, % . | Aggregates containing 11 to 30 platelets, % . | Aggregates containing 31 to 50 platelets, % . |
|---|---|---|---|---|
| Wild type | 60.3 ± 2.8 | 21.2 ± 2.3 | 13.7 ± 0.6 | 4.8 ± 0.6 |
| α2β1-/- | 72.8 ± 3.3 | 24.3 ± 2.8 | 2.8 ± 0.9 | 0.1 ± 0.1 |
| GPVI-FcRγ-/- | 97.0 ± 0.4 | 3.0 ± 0.4 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| GPVI-FcRγ-/-/α2β1-/- | 96.8 ± 1.5 | 3.2 ± 1.5 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| SLP-76-/- | 94.7 ± 1.9 | 5.1 ± 1.8 | 0.1 ± 0.1 | 0.1 ± 0.0 |
| LAT-/- | 75.2 ± 4.1 | 19.4 ± 2.8 | 4.8 ± 1.4 | 0.6 ± 0.2 |
| Low-GPVI | 92.7 ± 1.9 | 6.9 ± 1.8 | 0.3 ± 0.1 | 0.0 ± 0.0 |
The results shown are the mean ± SEM after analysis of the phase-contrast images (n = 5-10).