Drugs associated with aplastic anemia in the International Aplastic Anemia Agranulocytosis Study.*
| Drug . | Stratified Risk Estimate# . | Multivariate Relative Risk Estimate# . |
|---|---|---|
| Nonsteroidal analgesics | ||
| butazones | 3.7 (1.9-7.2)# | 5.1 (2.1-12)# |
| indomethacin | 7.1 (3.4-15) | 8.2 (3.3-20) |
| piroxicam | 9.8 (3.3-29) | 7.4 (2.1-26) |
| diclofenac | 4.6 (2.0-11) | 4.2 (1.6-11) |
| Antibiotics | ||
| sulfonamides** | 2.8 (1.1-7.3) | 2.2 (0.6-7.4) |
| Antithyroid drugs | 16 (4.8-54) | 11 (2.0-56) |
| Cardiovascular drugs | ||
| furosemide | 3.3 (1.6-7.0) | 3.1 (1.2-8.0) |
| Psychotropic drugs | ||
| phenothiazines | 3.0 (1.1-8.2) | 1.6 (0.4-7.4) |
| Corticosteroids | 5.0 (2.8-8.9) | 3.5 (1.6-7.7) |
| Penicillamine | ∞ | |
| Allopurinol | 7.3 (3.0-17) | 5.9 (1.8-19) |
| Gold | 29 (9.7-89) |
| Drug . | Stratified Risk Estimate# . | Multivariate Relative Risk Estimate# . |
|---|---|---|
| Nonsteroidal analgesics | ||
| butazones | 3.7 (1.9-7.2)# | 5.1 (2.1-12)# |
| indomethacin | 7.1 (3.4-15) | 8.2 (3.3-20) |
| piroxicam | 9.8 (3.3-29) | 7.4 (2.1-26) |
| diclofenac | 4.6 (2.0-11) | 4.2 (1.6-11) |
| Antibiotics | ||
| sulfonamides** | 2.8 (1.1-7.3) | 2.2 (0.6-7.4) |
| Antithyroid drugs | 16 (4.8-54) | 11 (2.0-56) |
| Cardiovascular drugs | ||
| furosemide | 3.3 (1.6-7.0) | 3.1 (1.2-8.0) |
| Psychotropic drugs | ||
| phenothiazines | 3.0 (1.1-8.2) | 1.6 (0.4-7.4) |
| Corticosteroids | 5.0 (2.8-8.9) | 3.5 (1.6-7.7) |
| Penicillamine | ∞ | |
| Allopurinol | 7.3 (3.0-17) | 5.9 (1.8-19) |
| Gold | 29 (9.7-89) |