Table 2.

Gene deficiencies that confer susceptibility to antigen receptor translocations in lymphoma.

Gene
Function
Species
Lymphoma Type
Translocation
ATM   DNA damage response   Human   T-NHL; T-PLL   t(7;14)  
ATM   DNA damage response   Mice   Thymic   Multiple  
NBS1   DNA damage response   Human   B-NHL; T-NHL   Unknown  
BLM   Chromosomal maintenance   Human   NHL   Unknown  
*p53   DNA damage response   Mice   Pro-B   t(12;15) IgH-cmyc  
**DNA-PKcs   Rejoin V(D)J coding ends   Mice   Pro-B   t(12;15) IgH-cmyc t(12;12) IgH-nmyc  
**XRCC4   NHEJ pathway   Mice   Pro-B   t(12;15) IgH-cmyc  
**Ku86   NHEJ pathway   Mice   Pro-B   t(12;15) IgH-cmyc  
Gene
Function
Species
Lymphoma Type
Translocation
ATM   DNA damage response   Human   T-NHL; T-PLL   t(7;14)  
ATM   DNA damage response   Mice   Thymic   Multiple  
NBS1   DNA damage response   Human   B-NHL; T-NHL   Unknown  
BLM   Chromosomal maintenance   Human   NHL   Unknown  
*p53   DNA damage response   Mice   Pro-B   t(12;15) IgH-cmyc  
**DNA-PKcs   Rejoin V(D)J coding ends   Mice   Pro-B   t(12;15) IgH-cmyc t(12;12) IgH-nmyc  
**XRCC4   NHEJ pathway   Mice   Pro-B   t(12;15) IgH-cmyc  
**Ku86   NHEJ pathway   Mice   Pro-B   t(12;15) IgH-cmyc  
*

in combination with deficiency of V(D)J rejoining components DNA-PKcs, Ku86, or XRCC4.

**

when combined with p53-null mutation.

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