Table 3.

Evolution of AML in the long-term follow-up of 3 previous studies on treatment with Epo and G-CSF


Category

Total no.

AML, no. (%)

Median observation time, mo*

Cumulative incidence of AML at 4 y, %
Total   124   33 (27)   24   30  
FAB     
    RA   28   7 (25)   43   21  
    RARS   40   2 (5)   32   6  
    RAEB   56   24 (43)   17   55  
IPSS     
    Low   33   4 (12)   59   6  
    Int-1   56   14 (25)   24   30  
    Int-2/High   26   12 (46)   8   67  
Predictive group     
    Good   42   12 (29)   34   27  
    Intermediate   44   7 (16)   20   18  
    Poor
 
16
 
7 (44)
 
11
 
83
 

Category

Total no.

AML, no. (%)

Median observation time, mo*

Cumulative incidence of AML at 4 y, %
Total   124   33 (27)   24   30  
FAB     
    RA   28   7 (25)   43   21  
    RARS   40   2 (5)   32   6  
    RAEB   56   24 (43)   17   55  
IPSS     
    Low   33   4 (12)   59   6  
    Int-1   56   14 (25)   24   30  
    Int-2/High   26   12 (46)   8   67  
Predictive group     
    Good   42   12 (29)   34   27  
    Intermediate   44   7 (16)   20   18  
    Poor
 
16
 
7 (44)
 
11
 
83
 
*

Median observation time from start of study, censored at time of AML.