Status of the early TCR signaling machinery in patients with T-CVID
. | Phosphorylation/activity . | Subcellular locus . |
---|---|---|
CD3ζ* | Defective | ND |
ZAP-70* | Defective | Normal |
Lck† | Normal | Normal |
Fyn‡ | ND | Normal |
. | Phosphorylation/activity . | Subcellular locus . |
---|---|---|
CD3ζ* | Defective | ND |
ZAP-70* | Defective | Normal |
Lck† | Normal | Normal |
Fyn‡ | ND | Normal |
Protein expression and cDNA sequences were normal.
ND indicates not determined.
See Boncristiano et al20 for patients T-CVID1 and T-CVID2 and Figures S1 and S2 for patients T-CVID3 and T-CVID4.
See Boncristiano et al20 for patients T-CVID1 and T-CVID2 and Figures S2 and S3 for patients T-CVID3 and T-CVID4.
Data presented in this article (Figure 1 and data not shown).