Table 1.

Status of the early TCR signaling machinery in patients with T-CVID




Phosphorylation/activity

Subcellular locus
CD3ζ*  Defective   ND  
ZAP-70*  Defective   Normal  
Lck  Normal   Normal  
Fyn
 
ND
 
Normal
 



Phosphorylation/activity

Subcellular locus
CD3ζ*  Defective   ND  
ZAP-70*  Defective   Normal  
Lck  Normal   Normal  
Fyn
 
ND
 
Normal
 

Protein expression and cDNA sequences were normal.

ND indicates not determined.

*

See Boncristiano et al20  for patients T-CVID1 and T-CVID2 and Figures S1 and S2 for patients T-CVID3 and T-CVID4.

See Boncristiano et al20  for patients T-CVID1 and T-CVID2 and Figures S2 and S3 for patients T-CVID3 and T-CVID4.

Data presented in this article (Figure 1 and data not shown).

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