RHAMM/CD168-derived T-cell epitope peptides predicted by computer algorithms
No. . | Peptide sequence . | Peptide position . | SYFPEITHI ranking . | BIMAS ranking . | PAProC proteasome type . |
|---|---|---|---|---|---|
| R1 | KLLEYIEEI | 232-240 | 1 | 2 | PII, PIII |
| R2 | KLQEELNKV | 671-679 | 2 | 1 | PI-PIII |
| R3 | ILSLELMKL | 165-173 | 4 | 4 | PI-PIII |
| R4 | KLQVTQRSL | 194-202 | 15 | > 20 | PIII |
| R5 | SLEENIVIL | 274-282 | 3 | > 20 | PII |
| R6 | NLNAEMQNL | 313-321 | > 20 | 8 | PI-PIII |
| R7 | SLLQQEKEL | 344-352 | 10 | 5 | PI-PIII |
| R8 | KLKGKEAEL | 419-427 | 6 | > 20 | PII |
| R9 | QLQLDAFEV | 594-602 | > 20 | 3 | PI |
| R10 | QLKSEVSKL | 650-658 | 11 | > 20 | PII, PIII |
No. . | Peptide sequence . | Peptide position . | SYFPEITHI ranking . | BIMAS ranking . | PAProC proteasome type . |
|---|---|---|---|---|---|
| R1 | KLLEYIEEI | 232-240 | 1 | 2 | PII, PIII |
| R2 | KLQEELNKV | 671-679 | 2 | 1 | PI-PIII |
| R3 | ILSLELMKL | 165-173 | 4 | 4 | PI-PIII |
| R4 | KLQVTQRSL | 194-202 | 15 | > 20 | PIII |
| R5 | SLEENIVIL | 274-282 | 3 | > 20 | PII |
| R6 | NLNAEMQNL | 313-321 | > 20 | 8 | PI-PIII |
| R7 | SLLQQEKEL | 344-352 | 10 | 5 | PI-PIII |
| R8 | KLKGKEAEL | 419-427 | 6 | > 20 | PII |
| R9 | QLQLDAFEV | 594-602 | > 20 | 3 | PI |
| R10 | QLKSEVSKL | 650-658 | 11 | > 20 | PII, PIII |
The designation, the position of the peptides (according to accession no. U29343), and the ranking numbers based on HLA- binding prediction algorithms (http://www.syfpeithi.de, 16 http://bimas.dcrt.nih.gov/molbio/hla_bind/17 ) are indicated. The digestion of RHAMM/CD 168 by the proteasome types I to III (PI-PIII) was analyzed by using the PAProC algorithm (http://www.paproc.de18 ). The respective proteasome types producing these potential peptide sequences are listed.