Table 2.

Clinical and genetic features of translocation and cyclin D (TC) molecular subgroups of multiple myeloma








Multiple trisomies

MRI positive
TC group
Recurrent tx
Gene(s) at breakpoint
Dysregulated D cyclin
% of untreated patients
% of 30 relapsed patients
n
%*
PI greater than 0.2, %
n
%
6p21   6p21  CCND3  D3   3   3   7   29   14   5   100  
11q13   11q13  CCND1  D1   16   17   40   0   18   27   94 
D1   none   none   D1   34  10  81   93§  5§  57   86  
D1 + D2   none   none   D1 + D2   6  17  21   86§  43  13   100 
D2   none   none   D2   17   20   45   40   16   27   67  
none   none   none   none   2   3   6   33   17   4   100  
4p16   4p16  FGFR3/MMSET  D2   15   23   42   29§  21   28   57 
maf   16q23, 20q11  MAF, MAFB  D2   7   7   19   16§  32   11   55 
Total
 

 

 

 
100
 
100
 
261
 
50
 
17
 
172
 
79
 







Multiple trisomies

MRI positive
TC group
Recurrent tx
Gene(s) at breakpoint
Dysregulated D cyclin
% of untreated patients
% of 30 relapsed patients
n
%*
PI greater than 0.2, %
n
%
6p21   6p21  CCND3  D3   3   3   7   29   14   5   100  
11q13   11q13  CCND1  D1   16   17   40   0   18   27   94 
D1   none   none   D1   34  10  81   93§  5§  57   86  
D1 + D2   none   none   D1 + D2   6  17  21   86§  43  13   100 
D2   none   none   D2   17   20   45   40   16   27   67  
none   none   none   none   2   3   6   33   17   4   100  
4p16   4p16  FGFR3/MMSET  D2   15   23   42   29§  21   28   57 
maf   16q23, 20q11  MAF, MAFB  D2   7   7   19   16§  32   11   55 
Total
 

 

 

 
100
 
100
 
261
 
50
 
17
 
172
 
79
 

– indicates not applicable.

*

Percentage of samples within each TC group with gene expression profiling evidence for 3 or more trisomies of chromosomes 3, 5, 7, 9, 11, 15, 19, or 21

Percentage of samples within each TC group with an expression PI greater then 0.2. There is a PI >0.2 in 67% of relapsed samples, and 10% of newly diagnosed MM (P < 10-13)

Percentage of samples within each TC group from patients with lytic lesions on MRI. In pairwise comparisons, each of groups 11q13, D1, and D1 + D2 is significantly different (P < .05) from each of groups D2, 4p16, and maf

§

P < .001

P < .05

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