Expression of HAS1 variants correlates with production of extracellular and/or intracellular HA
HAS RNA expression pattern . | HA production . | No. patients . |
|---|---|---|
| HAS1Va, HAS3 | Extracellular HA matrix | 2 |
| HAS1Va, HAS1, HAS3 | Extracellular HA matrix | 3 |
| HAS1Va, HAS1Vb, HAS1, HAS3 | Extracellular HA matrix & intracellular HA | 3 |
| HAS1Vb, HAS1, HAS3 | Intracellular HA and very weak extracellular HA | 2 |
| HAS1, HAS3 | No HA production | 3 |
| HAS3 | No HA production | 2 |
HAS RNA expression pattern . | HA production . | No. patients . |
|---|---|---|
| HAS1Va, HAS3 | Extracellular HA matrix | 2 |
| HAS1Va, HAS1, HAS3 | Extracellular HA matrix | 3 |
| HAS1Va, HAS1Vb, HAS1, HAS3 | Extracellular HA matrix & intracellular HA | 3 |
| HAS1Vb, HAS1, HAS3 | Intracellular HA and very weak extracellular HA | 2 |
| HAS1, HAS3 | No HA production | 3 |
| HAS3 | No HA production | 2 |
Summary of the expression of HAS1, its novel variants, and HAS3 genes in PBMCs obtained from 15 MM patients. In conjunction with gene expression analysis, we conducted PEA and HA staining on PBMC B cells obtained from aliquots of the same populations of cells from MM patients to evaluate the potential role of HAS1 variants in the enhanced production of extracellular and intracellular HA.