Multiple regression analysis of stage and laboratory variables with regard to Hb levels in 91 epithelial ovarian cancer patients
Covariate parameters . | Coefficient . | SE . | 95% Confidence Interval . | P . |
|---|---|---|---|---|
| Stage | -0.5906 | 0.2680 | -1.1372 to -0.0440 | .035 |
| Weight | -0.0326 | 0.0406 | -0.1150 to 0.0499 | .427 |
| BMI | 0.1125 | 0.1102 | -0.1112 to 0.3361 | .314 |
| CRP | 0.0029 | 0.0203 | -0.0384 to 0.0442 | .887 |
| Fbg | -0.0013 | 0.0020 | -0.0055 to 0.0029 | .528 |
| IL-1β | -0.0096 | 0.0131 | -0.0363 to 0.0171 | .468 |
| IL-6 | -0.0230 | 0.0111 | -0.0457 to -0.0004 | .046 |
| TNFα | -0.0122 | 0.0106 | -0.0337 to 0.0093 | .255 |
| ROS | -0.0014 | 0.0031 | -0.0078 to 0.0050 | .659 |
| GPx | 0.0000 | 0.0001 | -0.0002 to 0.0001 | .629 |
Covariate parameters . | Coefficient . | SE . | 95% Confidence Interval . | P . |
|---|---|---|---|---|
| Stage | -0.5906 | 0.2680 | -1.1372 to -0.0440 | .035 |
| Weight | -0.0326 | 0.0406 | -0.1150 to 0.0499 | .427 |
| BMI | 0.1125 | 0.1102 | -0.1112 to 0.3361 | .314 |
| CRP | 0.0029 | 0.0203 | -0.0384 to 0.0442 | .887 |
| Fbg | -0.0013 | 0.0020 | -0.0055 to 0.0029 | .528 |
| IL-1β | -0.0096 | 0.0131 | -0.0363 to 0.0171 | .468 |
| IL-6 | -0.0230 | 0.0111 | -0.0457 to -0.0004 | .046 |
| TNFα | -0.0122 | 0.0106 | -0.0337 to 0.0093 | .255 |
| ROS | -0.0014 | 0.0031 | -0.0078 to 0.0050 | .659 |
| GPx | 0.0000 | 0.0001 | -0.0002 to 0.0001 | .629 |
The dependent variable (Hb) in the regression equation, the number of patients observed (91), the number of terms in the regression equation (10), the coefficient of determination (R2 = 0.75) and P value (< .001) are used. The results showed that Hb is predicted only by stage and IL-6 levels. In contrast to these parameters C-reactive protein (CRP), fibrinogen (Fbg), leptin, TNFα, reactive oxygen species (ROS), and glutathione peroxidase (GPx) showed a significant correlation with Hb at single regression analysis but failed to be independent factors for Hb levels in multiple regression analysis. Text in italics indicates that the P value is statistically significant (P < 0.5).
BMI indicates body mass index; IL, interleukin; TNF, tumor necrosis factor; ROS, reactive oxygen species; SOD, superoxide dismutase.