Doxorubicin pharmacokinetics
Pharmacokinetic parameter . | Mean for all dose levels, n = 35 . |
|---|---|
| Cmax, mg/mL | 18.0 ± 4.4 (11.1-29.9) |
| AUC, (mg/mL) × h | 2010 ± 802 (535-3600) |
| CL, mL/h | 33.6 ± 20.0 (12.0-123.61) |
| Vss, mL | 3090 ± 1150 (468-6020) |
| t1/2, h | 79.9 ± 29.5 (27.0-167.0) |
Pharmacokinetic parameter . | Mean for all dose levels, n = 35 . |
|---|---|
| Cmax, mg/mL | 18.0 ± 4.4 (11.1-29.9) |
| AUC, (mg/mL) × h | 2010 ± 802 (535-3600) |
| CL, mL/h | 33.6 ± 20.0 (12.0-123.61) |
| Vss, mL | 3090 ± 1150 (468-6020) |
| t1/2, h | 79.9 ± 29.5 (27.0-167.0) |
All values are expressed as the mean ± the standard deviation. The range is shown in parentheses. Cmax indicates peak plasma concentration after single dose administration; AUC, area under the concentration time curve; CL, total plasma body clearance; Vss, volume of distribution at steady state; and t1/2, half-life.