Table 4.

Distribution of pretreatment risk factors by randomized postremission regimen




HiDAC alone, no. (%)

Multiagent CT, no. (%)

Total, no. (%)
Age, y    
   Younger than 30   36 (24)   30 (19)   66 (21)  
   30-39   34 (22)   36 (23)   70 (23)  
   40-49   44 (29)   52 (33)   96 (31)  
   50-59   39 (25)   38 (24)   77 (25)  
WBC count, × 103/μL    
   7 or lower   52 (35)   44 (29)   96 (32)  
   7.1-30   42 (28)   50 (32)   92 (30)  
   Greater than 30   56 (37)   60 (38)   116 (38)  
CD56    
   Negative   84 (90)   86 (84)   170 (87)  
   Positive   9 (10)   16 (16)   25 (13)  
Cytogenetic risk groups (cumulative incidence of relapse)*    
   Favorable   27 (18)   21 (13)   48 (16)  
   Intermediate   54 (35)   66 (42)   120 (39)  
   Unfavorable   11 (7)   4 (3)   15 (5)  
   Not classified  5 (3)   5 (3)   10 (3)  
   t(15;17)   5 (3)   4 (3)   9 (3)  
   Inadequate   51 (33)   56 (36)   107 (35)  
FAB    
   Non-M4 or M5   108 (71)   102 (65)   210 (68)  
   M4 or M5
 
45 (29)
 
54 (35)
 
99 (32)
 



HiDAC alone, no. (%)

Multiagent CT, no. (%)

Total, no. (%)
Age, y    
   Younger than 30   36 (24)   30 (19)   66 (21)  
   30-39   34 (22)   36 (23)   70 (23)  
   40-49   44 (29)   52 (33)   96 (31)  
   50-59   39 (25)   38 (24)   77 (25)  
WBC count, × 103/μL    
   7 or lower   52 (35)   44 (29)   96 (32)  
   7.1-30   42 (28)   50 (32)   92 (30)  
   Greater than 30   56 (37)   60 (38)   116 (38)  
CD56    
   Negative   84 (90)   86 (84)   170 (87)  
   Positive   9 (10)   16 (16)   25 (13)  
Cytogenetic risk groups (cumulative incidence of relapse)*    
   Favorable   27 (18)   21 (13)   48 (16)  
   Intermediate   54 (35)   66 (42)   120 (39)  
   Unfavorable   11 (7)   4 (3)   15 (5)  
   Not classified  5 (3)   5 (3)   10 (3)  
   t(15;17)   5 (3)   4 (3)   9 (3)  
   Inadequate   51 (33)   56 (36)   107 (35)  
FAB    
   Non-M4 or M5   108 (71)   102 (65)   210 (68)  
   M4 or M5
 
45 (29)
 
54 (35)
 
99 (32)
 

For HiDAC alone, n = 153; for multiagent CT, 156; and for total, 309.

*

Cumulative incidence of relapse is defined in the text and in Byrd et al.11 

Includes one patient with t(9;22) who received MCT