Cytogenetic findings in 323 patients with newly diagnosed AML
Cytogenetic finding . | No. patients (%) . |
|---|---|
| Normal | 141 (44) |
| t(15;17)(q22;q12≈21) | 12 (4) |
| t(9;22)(q34;q11.2) | 1 (< 1) |
| t(8;21)(q22;q22) | 29 (9) |
| inv(16)(p13q22) or t(16;16)(p13;q22) | 32 (10) |
| t(9;11)(p22;q23) | 14 (4) |
| t(6;9)(p23;q34) | 3 (< 1) |
| del(20)(q11 or q11q13) | 2 (< 1) |
| inv(3)(q21q26) and variants | 8 (2) |
| + 13 sole | 3 (< 1) |
| + 8 sole | 6 (2) |
| + 21 sole | 3 (< 1) |
| + 11 sole | 2 (< 1) |
| - Y sole | 3 (< 1) |
| - 7 sole | 4 (1) |
| Other balanced translocations involving band 11q23 | 10 (3) |
| Other single trisomy | 3 (< 1) |
| Other single monosomy | 1 (< 1) |
| del(12)(p11≈13) | 2 (< 1) |
| del(5)(q11≈31q31≈35) | 4 (1) |
| Single structural other than those listed above | 16 (5) |
| 2 abnormalities other than those listed above | 13 (4) |
| 3 or more abnormalities other than those listed above | 11 (3) |
Cytogenetic finding . | No. patients (%) . |
|---|---|
| Normal | 141 (44) |
| t(15;17)(q22;q12≈21) | 12 (4) |
| t(9;22)(q34;q11.2) | 1 (< 1) |
| t(8;21)(q22;q22) | 29 (9) |
| inv(16)(p13q22) or t(16;16)(p13;q22) | 32 (10) |
| t(9;11)(p22;q23) | 14 (4) |
| t(6;9)(p23;q34) | 3 (< 1) |
| del(20)(q11 or q11q13) | 2 (< 1) |
| inv(3)(q21q26) and variants | 8 (2) |
| + 13 sole | 3 (< 1) |
| + 8 sole | 6 (2) |
| + 21 sole | 3 (< 1) |
| + 11 sole | 2 (< 1) |
| - Y sole | 3 (< 1) |
| - 7 sole | 4 (1) |
| Other balanced translocations involving band 11q23 | 10 (3) |
| Other single trisomy | 3 (< 1) |
| Other single monosomy | 1 (< 1) |
| del(12)(p11≈13) | 2 (< 1) |
| del(5)(q11≈31q31≈35) | 4 (1) |
| Single structural other than those listed above | 16 (5) |
| 2 abnormalities other than those listed above | 13 (4) |
| 3 or more abnormalities other than those listed above | 11 (3) |
Cytogenetic findings are prioritized in the order listed. Thus, for patients with cytogenetic abnormalities, those with t(15;17) are first identified and removed from further consideration. Among remaining patients, those with t(9;22) are next removed, followed by those with t(8;21), and so forth. As a result, for example, a patient with del(20)(q11) might also have a del(5)(q13q31) but here would be listed in the del(20)(q11 or q11q13) group.