Immunophenotype and genotype of LALA-94 patients classified by TCR status
. | Immature 31 . | Pre-αβ 29 . | TCR-αβ 18 . | TCR-αβ 13 . | Total 91 . |
|---|---|---|---|---|---|
| Patients, N (%) | 31 (34%) | 29 (32%) | 18 (20%) | 13 (14%) | 91 (100%) |
| Phenotype, % | |||||
| CD34 | 58 | 11 | 50 | 23 | 37 |
| CD13/33 | 23 | 7 | 24 | 17 | 15 |
| CD5 | 87 | 97 | 100 | 92 | 93 |
| CD2 | 47 | 100 | 83 | 31 | 68 |
| CD4/8 DN | 74 | 7 | 22 | 15 | 34 |
| CD4/8 DP | 3 | 86 | 61 | 31 | 45 |
| CD4 or CD8 | 23 | 7 | 17 | 54 | 21 |
| CD1a | 20 | 81 | 53 | 31 | 47 |
| CD10 | 30 | 39 | 44 | 46 | 38 |
| TdT | 80 | 100 | 83 | 100 | 90 |
| Genetic abnormalities, n | |||||
| Analyzed for MG | 29 | 28 | 13 | 11 | 81 |
| CALM-AF10 | 5 | 0 | 0 | 3 | 8 |
| HOX11L2 | 6 | 1 | 2 | 1 | 10 |
| SIL-TAL1 | 1 | 4 | 5 | 0 | 10 |
| HOX11 | 2 | 8 | 0 | 1 | 11 |
| MG-negative | 15 | 15 | 6 | 6 | 42 |
| Analyzed for TAL1, LMO2, and LYL | 24 | 25 | 12 | 8 | 69 |
| TAL1 | 6 | 9 | 7 | 0 | 22 |
| LMO2 | 9 | 4 | 1 | 1 | 15 |
| LYL | 5 | 1 | 1 | 1 | 8 |
. | Immature 31 . | Pre-αβ 29 . | TCR-αβ 18 . | TCR-αβ 13 . | Total 91 . |
|---|---|---|---|---|---|
| Patients, N (%) | 31 (34%) | 29 (32%) | 18 (20%) | 13 (14%) | 91 (100%) |
| Phenotype, % | |||||
| CD34 | 58 | 11 | 50 | 23 | 37 |
| CD13/33 | 23 | 7 | 24 | 17 | 15 |
| CD5 | 87 | 97 | 100 | 92 | 93 |
| CD2 | 47 | 100 | 83 | 31 | 68 |
| CD4/8 DN | 74 | 7 | 22 | 15 | 34 |
| CD4/8 DP | 3 | 86 | 61 | 31 | 45 |
| CD4 or CD8 | 23 | 7 | 17 | 54 | 21 |
| CD1a | 20 | 81 | 53 | 31 | 47 |
| CD10 | 30 | 39 | 44 | 46 | 38 |
| TdT | 80 | 100 | 83 | 100 | 90 |
| Genetic abnormalities, n | |||||
| Analyzed for MG | 29 | 28 | 13 | 11 | 81 |
| CALM-AF10 | 5 | 0 | 0 | 3 | 8 |
| HOX11L2 | 6 | 1 | 2 | 1 | 10 |
| SIL-TAL1 | 1 | 4 | 5 | 0 | 10 |
| HOX11 | 2 | 8 | 0 | 1 | 11 |
| MG-negative | 15 | 15 | 6 | 6 | 42 |
| Analyzed for TAL1, LMO2, and LYL | 24 | 25 | 12 | 8 | 69 |
| TAL1 | 6 | 9 | 7 | 0 | 22 |
| LMO2 | 9 | 4 | 1 | 1 | 15 |
| LYL | 5 | 1 | 1 | 1 | 8 |
The proportion of patients expressing each immunophenotypic marker is stated, as is the number of patients with a given genetic marker within each TCR-defined category. DP indicates double positive; DN, double negative; and MG, molecular genetic (ie, HOX11, HOX11L2, CALM-AF10, SIL-TAL1).