Effect of CYC202 (5 μg/mL), fludarabine (20 μM), or irradiation (5 Gy) on apoptosis in 26 B-CLL tumors
. | . | % apoptotic cells, mean (95% CI) . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| Genotype . | No. . | No drug . | CYC202 . | Fludarabine . | Irradiation . | |||
| After 24 hours | ||||||||
| All types | 26 | 23.3 (18.7-27.9) | 83.9 (78.6-89.2) | 28.7* (24.3-33.1) | 33.5* (27.6-39.3) | |||
| ATM/TP53 wt | 15 | 22.5 (17.3-27.7) | 82.5 (73.5-91.5) | 29.3* (23.5-35.1) | 36.3* (29.1-43.5) | |||
| ATM mut | 7 | 19.0 (11.1-26.9) | 84.2 (77.4-91.0) | 22.9* (15.2-30.6) | 21.7* (12.9-30.5) | |||
| TP53 mut | 4 | 33.8 (9.9-57.7) | 88.6 (77.6-99.6) | 36.7† (18.5-54.9) | 46.8‡ (27.2-66.4) | |||
| After 48 hours | ||||||||
| All types | 26 | 25.8 (20.8-30.8) | 87.5 (83.1-91.9) | 64.2* (53.9-74.5) | 47.0* (39.2-54.8) | |||
| ATM/TP53 wt | 15 | 24.1 (18.2-30.0) | 87.6 (80.9-94.3) | 69.0‡ (54.8-83.2) | 52.8* (42.7-63.0) | |||
| ATM mut | 7 | 20.7 (12.2-29.2) | 84.5 (75.4-93.6) | 48.4† (28.2-68.6) | 31.4* (17.7-45.2) | |||
| TP53 mut | 4 | 41.3 (25.2-57.4) | 92.3 (83.8-100) | 73.6 (47.8-99.4) | 54.3‡ (40.2-68.3) | |||
| After 72 hours | ||||||||
| All types | 22 | 31.7 (25.3-38.1) | 89.3 (84.0-94.6) | 79.0 (67.1-90.8) | 62.2* (51.1-73.3) | |||
| ATM/TP53 wt | 12 | 28.8 (22.8-34.9) | 92.8 (88.1-97.5) | 89.1 (78.2-99.9) | 73.4‡ (61.2-85.6) | |||
| ATM mut | 6 | 22.4 (14.4-30.4) | 79.7 (62.3-97.1) | 53.9 (20.3-87.6) | 39.0‡ (16.1-61.9) | |||
| TP53 mut | 4 | 54.4 (38.5-70.4) | 93.4 (85.8-100) | 87.6 (74.5-100) | 67.5‡ (64.9-70.0) | |||
. | . | % apoptotic cells, mean (95% CI) . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| Genotype . | No. . | No drug . | CYC202 . | Fludarabine . | Irradiation . | |||
| After 24 hours | ||||||||
| All types | 26 | 23.3 (18.7-27.9) | 83.9 (78.6-89.2) | 28.7* (24.3-33.1) | 33.5* (27.6-39.3) | |||
| ATM/TP53 wt | 15 | 22.5 (17.3-27.7) | 82.5 (73.5-91.5) | 29.3* (23.5-35.1) | 36.3* (29.1-43.5) | |||
| ATM mut | 7 | 19.0 (11.1-26.9) | 84.2 (77.4-91.0) | 22.9* (15.2-30.6) | 21.7* (12.9-30.5) | |||
| TP53 mut | 4 | 33.8 (9.9-57.7) | 88.6 (77.6-99.6) | 36.7† (18.5-54.9) | 46.8‡ (27.2-66.4) | |||
| After 48 hours | ||||||||
| All types | 26 | 25.8 (20.8-30.8) | 87.5 (83.1-91.9) | 64.2* (53.9-74.5) | 47.0* (39.2-54.8) | |||
| ATM/TP53 wt | 15 | 24.1 (18.2-30.0) | 87.6 (80.9-94.3) | 69.0‡ (54.8-83.2) | 52.8* (42.7-63.0) | |||
| ATM mut | 7 | 20.7 (12.2-29.2) | 84.5 (75.4-93.6) | 48.4† (28.2-68.6) | 31.4* (17.7-45.2) | |||
| TP53 mut | 4 | 41.3 (25.2-57.4) | 92.3 (83.8-100) | 73.6 (47.8-99.4) | 54.3‡ (40.2-68.3) | |||
| After 72 hours | ||||||||
| All types | 22 | 31.7 (25.3-38.1) | 89.3 (84.0-94.6) | 79.0 (67.1-90.8) | 62.2* (51.1-73.3) | |||
| ATM/TP53 wt | 12 | 28.8 (22.8-34.9) | 92.8 (88.1-97.5) | 89.1 (78.2-99.9) | 73.4‡ (61.2-85.6) | |||
| ATM mut | 6 | 22.4 (14.4-30.4) | 79.7 (62.3-97.1) | 53.9 (20.3-87.6) | 39.0‡ (16.1-61.9) | |||
| TP53 mut | 4 | 54.4 (38.5-70.4) | 93.4 (85.8-100) | 87.6 (74.5-100) | 67.5‡ (64.9-70.0) | |||