Alignment of Tat sequences (the first 15 aa of the second exon, corresponding to aa 73 to 86 of Tat from HXB2/III B HIV-1) from different HIV-1 and HIV-2 strains
HIV-1, laboratory-adapted | |
| III B | QPTSQSRGDPTGPKE |
| HXB2 | -----P--------- |
| HIV-1, wild type | |
| Consensus_A1 | --IP-TQ-VS---E- |
| Consensus_A2 | -SLP-TQRVS---E- |
| Consensus_B | --A--P--------- |
| Consensus_C | --LP-T------SE- |
| Consensus_D | --S--P--------- |
| Consensus_F1 | --L--A--N------ |
| Consensus_F2 | --L--T-------E- |
| Consensus_G | --LPTT--N----E- |
| Consensus_H | --L-RT--------- |
| Consensus_O | --SI-T-RKQKRQE- |
| HIV-2, wild type | |
| Consensus_H2A | KSI-TRT--SQPT-Q |
| Consensus_H2B | KSL-ART--SQPT-K |
| H2AB | KSV-TRTRNSQPT-K |
| H2G | NESISAT-NXQPK-- |
| Consensus_MAC | K-I-NRT-HCQPE-A |
| Consensus_SMM | KSL-RRA-NCQPK-K |
| Conserved HIV-1/HIV-2 | *** *** * |
HIV-1, laboratory-adapted | |
| III B | QPTSQSRGDPTGPKE |
| HXB2 | -----P--------- |
| HIV-1, wild type | |
| Consensus_A1 | --IP-TQ-VS---E- |
| Consensus_A2 | -SLP-TQRVS---E- |
| Consensus_B | --A--P--------- |
| Consensus_C | --LP-T------SE- |
| Consensus_D | --S--P--------- |
| Consensus_F1 | --L--A--N------ |
| Consensus_F2 | --L--T-------E- |
| Consensus_G | --LPTT--N----E- |
| Consensus_H | --L-RT--------- |
| Consensus_O | --SI-T-RKQKRQE- |
| HIV-2, wild type | |
| Consensus_H2A | KSI-TRT--SQPT-Q |
| Consensus_H2B | KSL-ART--SQPT-K |
| H2AB | KSV-TRTRNSQPT-K |
| H2G | NESISAT-NXQPK-- |
| Consensus_MAC | K-I-NRT-HCQPE-A |
| Consensus_SMM | KSL-RRA-NCQPK-K |
| Conserved HIV-1/HIV-2 | *** *** * |
*Amino acidic residues present in strains of both kinds of viruses (sequences derived from Kuiken et al38 ).