Inhibitory effect of IMD-0354 and ST1571 on cell proliferation
. | IC50, μM . | . | |
|---|---|---|---|
| Cells . | IMD-0354 . | ST1571 . | |
| HMC-1 | 0.28 | 3.0 | |
| IC-2G559 | 0.25 | 0.03 | |
| IC-2V814 | 0.35 | > 10 | |
| IC-2WT | 0.77 | 0.25 | |
| CBhCMC | 3.0 | 0.15 | |
. | IC50, μM . | . | |
|---|---|---|---|
| Cells . | IMD-0354 . | ST1571 . | |
| HMC-1 | 0.28 | 3.0 | |
| IC-2G559 | 0.25 | 0.03 | |
| IC-2V814 | 0.35 | > 10 | |
| IC-2WT | 0.77 | 0.25 | |
| CBhCMC | 3.0 | 0.15 | |
Cells were incubated for 48 hours at the concentration of 2 × 105 cells/mL in phenol red free α-MEM containing 10% FCS (for HMC-1 and IC-2 cells) or 5% FCS (for CBhCMCs) with or without various concentrations of IMD-0354 or ST1571. IC50 was calculated from results of an MTT assay.