Characteristics of CVID patients
. | . | . | . | . | . | . | . | Leukocytes, 106/mm3 . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | pl.IL-7, pg/mL . | Age, y . | Sex . | Age at onset, y . | Splenomegaly . | Bronchiectasis . | Autoimmune phenomena . | CD4 . | CD8 . | CD19 . | ||
| 1 | 11.1 | 60 | M | 44 | 0 | 0 | 1 | 289 | 1486 | 47 | ||
| 2 | 12.4 | 52 | M | 45 | 0 | 0 | 1 | 922 | 2224 | 527 | ||
| 3 | 12.2 | 29 | M | 50 | 0 | 0 | 1 | 1107 | 600 | 199 | ||
| 4 | 12.4 | 38 | M | 3 | 1 | 1 | 1 | 632 | 199 | 124 | ||
| 5 | 16.3 | 31 | M | 13 | 1 | 1 | 0 | 1950 | 2396 | 442 | ||
| 6 | 12.4 | 30 | M | 10 | 0 | 0 | 0 | 915 | 595 | 336 | ||
| 7 | 10.9 | 63 | M | 10 | 1 | 1 | 0 | 1579 | 3979 | 21 | ||
| 8 | 14.9 | 22 | M | 12 | 1 | 1 | 1 | 3638 | 1629 | 1641 | ||
| 9 | 11.0 | 48 | M | 47 | 0 | 1 | 1 | 827 | 612 | 689 | ||
| 10 | 11.0 | 53 | W | 10 | 0 | 0 | 0 | 1046 | 1837 | 328 | ||
| 11 | 11.4 | 23 | M | 3 | 1 | 1 | 1 | 309 | 591 | 2 | ||
| 12 | 11.2 | 30 | M | 4 | 1 | 1 | 0 | 366 | 213 | 0 | ||
| 13 | 13.2 | 39 | W | 23 | 0 | 1 | 1 | 726 | 1219 | 30 | ||
| 14 | 7.3 | 70 | M | 27 | 1 | 1 | 1 | 225 | 722 | 106 | ||
| 15 | 1.9 | 26 | W | 19 | 1 | 1 | 1 | 1060 | 512 | 209 | ||
| 16 | 5.1 | 51 | M | 4 | 0 | 0 | 0 | 570 | 2297 | 153 | ||
| 17 | 1.1 | 64 | W | 52 | 0 | 1 | 0 | 385 | 520 | 185 | ||
| 18 | 4.9 | 57 | W | 31 | 1 | 1 | 0 | 731 | 295 | 30 | ||
| 19 | 3.1 | 43 | W | 40 | 0 | 1 | 1 | 1224 | 636 | 238 | ||
| 20 | 1.9 | 42 | W | 20 | 1 | 1 | 1 | 708 | 237 | 220 | ||
| 21 | 3.0 | 40 | M | 38 | 1 | 1 | 0 | 693 | 275 | 550 | ||
| 22 | 4.2 | 66 | M | 60 | 0 | 1 | 0 | 655 | 489 | 105 | ||
| 23 | 3.6 | 54 | M | 21 | 0 | 1 | 1 | 527 | 392 | 20 | ||
| 24 | 1.9 | 33 | M | 21 | 0 | 0 | 0 | 288 | 204 | 192 | ||
. | . | . | . | . | . | . | . | Leukocytes, 106/mm3 . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | pl.IL-7, pg/mL . | Age, y . | Sex . | Age at onset, y . | Splenomegaly . | Bronchiectasis . | Autoimmune phenomena . | CD4 . | CD8 . | CD19 . | ||
| 1 | 11.1 | 60 | M | 44 | 0 | 0 | 1 | 289 | 1486 | 47 | ||
| 2 | 12.4 | 52 | M | 45 | 0 | 0 | 1 | 922 | 2224 | 527 | ||
| 3 | 12.2 | 29 | M | 50 | 0 | 0 | 1 | 1107 | 600 | 199 | ||
| 4 | 12.4 | 38 | M | 3 | 1 | 1 | 1 | 632 | 199 | 124 | ||
| 5 | 16.3 | 31 | M | 13 | 1 | 1 | 0 | 1950 | 2396 | 442 | ||
| 6 | 12.4 | 30 | M | 10 | 0 | 0 | 0 | 915 | 595 | 336 | ||
| 7 | 10.9 | 63 | M | 10 | 1 | 1 | 0 | 1579 | 3979 | 21 | ||
| 8 | 14.9 | 22 | M | 12 | 1 | 1 | 1 | 3638 | 1629 | 1641 | ||
| 9 | 11.0 | 48 | M | 47 | 0 | 1 | 1 | 827 | 612 | 689 | ||
| 10 | 11.0 | 53 | W | 10 | 0 | 0 | 0 | 1046 | 1837 | 328 | ||
| 11 | 11.4 | 23 | M | 3 | 1 | 1 | 1 | 309 | 591 | 2 | ||
| 12 | 11.2 | 30 | M | 4 | 1 | 1 | 0 | 366 | 213 | 0 | ||
| 13 | 13.2 | 39 | W | 23 | 0 | 1 | 1 | 726 | 1219 | 30 | ||
| 14 | 7.3 | 70 | M | 27 | 1 | 1 | 1 | 225 | 722 | 106 | ||
| 15 | 1.9 | 26 | W | 19 | 1 | 1 | 1 | 1060 | 512 | 209 | ||
| 16 | 5.1 | 51 | M | 4 | 0 | 0 | 0 | 570 | 2297 | 153 | ||
| 17 | 1.1 | 64 | W | 52 | 0 | 1 | 0 | 385 | 520 | 185 | ||
| 18 | 4.9 | 57 | W | 31 | 1 | 1 | 0 | 731 | 295 | 30 | ||
| 19 | 3.1 | 43 | W | 40 | 0 | 1 | 1 | 1224 | 636 | 238 | ||
| 20 | 1.9 | 42 | W | 20 | 1 | 1 | 1 | 708 | 237 | 220 | ||
| 21 | 3.0 | 40 | M | 38 | 1 | 1 | 0 | 693 | 275 | 550 | ||
| 22 | 4.2 | 66 | M | 60 | 0 | 1 | 0 | 655 | 489 | 105 | ||
| 23 | 3.6 | 54 | M | 21 | 0 | 1 | 1 | 527 | 392 | 20 | ||
| 24 | 1.9 | 33 | M | 21 | 0 | 0 | 0 | 288 | 204 | 192 | ||
Individual data for all CVID patients selected for in vitro analyses (n = 24; note that not all analyses were performed on all patients due to limited amounts of available material).
Splenomegaly is verified by computed tomography (CT) scan or ultrasonographic examination; bronchiectasis is detected using high-resolution CT.
M indicates men; W, women.