Table 4.

Transcript levels of inflammatory modulators in heart after LPS treatment


Transcript and genotype

Copy no. × 104/100 ng by time after LPS
0 h
3 h
6 h
24 h
48 h
TNFα      
   WT  ND   ND   1.8 ± 0.4   ND   ND  
   EPCRδ/δ  ND   1.6 ± 0.9   1.2 ± 0.5   ND   ND  
IL1β      
   WT  ND   ND   1.4 ± 0.4   ND   ND  
   EPCRδ/δ  ND   ND   1.1 ± 0.3   ND   ND  
IL6      
   WT  ND   21 ± 7   16 ± 4   1.4 ± 0.9   ND  
   EPCRδ/δ  ND   31 ± 7   14 ± 4   4.9 ± 4.4   ND  
MIP-2      
   WT  ND   2.9 ± 2.1   22 ± 1   2.7 ± 0.8   8.2 ± 4  
   EPCRδ/δ  ND   690 ± 21  620 ± 230  13 ± 6   15 ± 10  
MCP-1      
   WT  ND   140 ± 39   290 ± 110   37 ± 17   38 ± 13  
   EPCRδ/δ  ND   200 ± 40   200 ± 44   9.5 ± 3.3   21 ± 7  
iNOS      
   WT  ND   ND   3.9 ± 1.0   ND   ND  
   EPCRδ/δ  ND   3.1 ± 2.1   3.9 ± 0.5   ND   ND  
HIF1α      
   WT  11 ± 5   14 ± 5   75 ± 18   55 ± 18   42 ± 10  
   EPCRδ/δ  19 ± 5   48 ± 12  93 ± 14   35 ± 18   22 ± 6  
VEGF      
   WT  15 ± 2   11 ± 2   20 ± 5   26 ± 9   24 ± 13  
   EPCRδ/δ
 
26 ± 7
 
44 ± 23
 
16 ± 3
 
13 ± 4
 
26 ± 7
 

Transcript and genotype

Copy no. × 104/100 ng by time after LPS
0 h
3 h
6 h
24 h
48 h
TNFα      
   WT  ND   ND   1.8 ± 0.4   ND   ND  
   EPCRδ/δ  ND   1.6 ± 0.9   1.2 ± 0.5   ND   ND  
IL1β      
   WT  ND   ND   1.4 ± 0.4   ND   ND  
   EPCRδ/δ  ND   ND   1.1 ± 0.3   ND   ND  
IL6      
   WT  ND   21 ± 7   16 ± 4   1.4 ± 0.9   ND  
   EPCRδ/δ  ND   31 ± 7   14 ± 4   4.9 ± 4.4   ND  
MIP-2      
   WT  ND   2.9 ± 2.1   22 ± 1   2.7 ± 0.8   8.2 ± 4  
   EPCRδ/δ  ND   690 ± 21  620 ± 230  13 ± 6   15 ± 10  
MCP-1      
   WT  ND   140 ± 39   290 ± 110   37 ± 17   38 ± 13  
   EPCRδ/δ  ND   200 ± 40   200 ± 44   9.5 ± 3.3   21 ± 7  
iNOS      
   WT  ND   ND   3.9 ± 1.0   ND   ND  
   EPCRδ/δ  ND   3.1 ± 2.1   3.9 ± 0.5   ND   ND  
HIF1α      
   WT  11 ± 5   14 ± 5   75 ± 18   55 ± 18   42 ± 10  
   EPCRδ/δ  19 ± 5   48 ± 12  93 ± 14   35 ± 18   22 ± 6  
VEGF      
   WT  15 ± 2   11 ± 2   20 ± 5   26 ± 9   24 ± 13  
   EPCRδ/δ
 
26 ± 7
 
44 ± 23
 
16 ± 3
 
13 ± 4
 
26 ± 7
 

n = 7 to 11 mice for the various experiments.

*Transcript expression levels below 1.0 × 104 molecules/100 ng total RNA were considered not detectable (ND) in this method.

P < .05

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